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impdh2.L IMP (inosine 5'-monophosphate) dehydrogenase 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399236, updated on 18-Sep-2024

Summary

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Official Symbol
impdh2.L
Official Full Name
IMP (inosine 5'-monophosphate) dehydrogenase 2 L homeolog
Primary source
Xenbase:XB-GENE-17345296
Locus tag
XELAEV_18024032mg
See related
EnsemblRapid:ENSXLAG00005027452
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
imp2; impdh2
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Genomic context

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See impdh2.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
16
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (137256029..137276528, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (132018514..132039178, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121403124 Neighboring gene DALR anticodon binding domain containing 3 L homeolog Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 L homeolog Neighboring gene glutamine-rich 1 L homeolog Neighboring gene glutaminyl-tRNA synthetase 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC53611

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables IMP dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within GMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IMP (inosine 5'-monophosphate) dehydrogenase 2 L homeolog; inosine 5'-phosphate dehydrogenase 2
NP_001083990.1
XP_018112060.1
XP_018112062.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090521.1 → NP_001083990.1  IMP (inosine 5'-monophosphate) dehydrogenase 2 L homeolog

    See identical proteins and their annotated locations for NP_001083990.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044122
    UniProtKB/TrEMBL
    A0A974HQ60, Q7ZXT8
    Related
    ENSXLAP00005082113.1, ENSXLAT00005083727.1
    Conserved Domains (3) summary
    cd00381
    Location:29 → 480
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:115 → 230
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:16 → 510
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    137256029..137276528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018256571.2 → XP_018112060.1  inosine 5'-phosphate dehydrogenase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8J0UZ33
    Related
    ENSXLAP00005081683.1, ENSXLAT00005083294.1

  2. XM_018256573.2 → XP_018112062.1  inosine 5'-phosphate dehydrogenase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8J0UYU8
    Related
    ENSXLAP00005081797.1, ENSXLAT00005083408.1
Nucleotide Protein Strain
Heading Accession and Version

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