hspd1.S heat shock protein family D (Hsp60) member 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hspd1.S
Official Full Name: heat shock protein family D (Hsp60) member 1 S homeolog
Primary source: Xenbase:XB-GENE-980064
Locus tag: XELAEV_18047428mg
See related: EnsemblRapid:ENSXLAG00005016940 AllianceGenome:Xenbase:XB-GENE-980064
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: hld4; cpn60; groel; hsp60; hsp65; hspd1; spg13; chaperonin
Summary: Predicted to enable ATP binding activity; ATP-dependent protein folding chaperone; and protein-folding chaperone binding activity. Predicted to act upstream of or within several processes, including mitochondrial unfolded protein response; positive regulation of cytokine production; and protein refolding. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Is expressed in anatomical system; mesenchyme; and pharyngeal arch. Human ortholog(s) of this gene implicated in artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (82871097..82886371, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (76176093..76191401, complement)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic mitochondrial changes	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial unfolded protein response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interferon-alpha production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein refolding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock protein family D (Hsp60) member 1 S homeolog

Names: heat shock 60kDa protein 1 (chaperonin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090501.1 → NP_001083970.1 heat shock protein family D (Hsp60) member 1 S homeolog

See identical proteins and their annotated locations for NP_001083970.1

Status: PROVISIONAL

Source sequence(s)

BC072058

UniProtKB/TrEMBL

A0A974BVA5, Q6IP60, Q7ZTR6

Related

ENSXLAP00005049957.1, ENSXLAT00005051098.1

Conserved Domains (2) summary

PTZ00114
Location:21 → 555

PTZ00114; Heat shock protein 60; Provisional

cd03344
Location:28 → 548

GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

82871097..82886371 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)