hey1.S hes related family bHLH transcription factor with YRPW motif 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hey1.S
Official Full Name: hes related family bHLH transcription factor with YRPW motif 1 S homeolog
Primary source: Xenbase:XB-GENE-865637
Locus tag: XELAEV_18033820mg
See related: EnsemblRapid:ENSXLAG00005028687 AllianceGenome:Xenbase:XB-GENE-865637
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: bc8; chf2; hey1; hrt1; oaf1; xbc8; herp2; hesr1
Summary: Enables bHLH transcription factor binding activity; protein dimerization activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including floor plate development; kidney development; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in anatomical system; ectoderm; mesenchyme; and pharyngeal arch. Orthologous to human HEY1 (hes related family bHLH transcription factor with YRPW motif 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6S

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (109361865..109366052, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6S	NC_030735.1 (100704094..100708281, complement)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the negative regulatory loops between BMP/Tbx2 and Gremlin or Hey1 are responsible for defining the territory of the pronephric nephron.
Title: Role of Tbx2 in defining the territory of the pronephric nephron.
XHRT1 plays an important role in glomerular development and early proximodistal patterning. [Xenopus HRT1]
Title: The Notch-effector HRT1 gene plays a role in glomerular development and patterning of the Xenopus pronephros anlagen.
HRT1 encodes a bhlh domain motif, a transcription repressor, which acts as an extended dimerization domain that contributes to the selection of partners.
Title: Sequences downstream of the bHLH domain of the Xenopus hairy-related transcription factor-1 act as an extended dimerization domain that contributes to the selection of the partners.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circulatory system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within floor plate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glomus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proximal/distal pattern formation involved in pronephric nephron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within specification of proximal tubule identity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hairy/enhancer-of-split related with YRPW motif protein 1

Names: HRT-1; XHRT1; XHey-1; bHLH protein Hesr-1/Hey1; hairy and enhancer of split-related protein 1; hairy-related transcription factor 1; hairy/enhancer-of-split related with YRPW motif 1; hesr-1; protein xbc8; xHRT-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090457.1 → NP_001083926.1 hairy/enhancer-of-split related with YRPW motif protein 1

See identical proteins and their annotated locations for NP_001083926.1

Status: PROVISIONAL

Source sequence(s)

BC084410

UniProtKB/Swiss-Prot

Q9I8A3

UniProtKB/TrEMBL

A0A974CKQ3

Related

ENSXLAP00005085430.1, ENSXLAT00005087092.1

Conserved Domains (2) summary

smart00511
Location:115 → 161

ORANGE; Orange domain

cd00083
Location:45 → 102

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

109361865..109366052 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)