egr1.L early growth response 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: egr1.L
Official Full Name: early growth response 1 L homeolog
Primary source: Xenbase:XB-GENE-853419
Locus tag: XELAEV_18017353mg
See related: AllianceGenome:Xenbase:XB-GENE-853419
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: egr; egr1; tis8; at225; egr-1; g0s30; Xegr-1; egr1-a; egr1-b; ngfi-a; znf225; EGR-1-A; krox-24; zif-268
Summary: Predicted to enable several functions, including DNA binding activity; promoter-specific chromatin binding activity; and zinc ion binding activity. Predicted to act upstream of or within circadian regulation of gene expression and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Is expressed in mesoderm. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 3L

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (55550958..55554295)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (41098409..41101746)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded methylated DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables hemi-methylated DNA-binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: early growth response protein 1-A

Names: early growth response protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090393.1 → NP_001083862.1 early growth response protein 1-A

See identical proteins and their annotated locations for NP_001083862.1

Status: PROVISIONAL

Source sequence(s)

BC072770

UniProtKB/Swiss-Prot

Q6GQH4, Q9I831

UniProtKB/TrEMBL

A0A974D907, A0A974DBF0

Conserved Domains (5) summary

sd00017
Location:308 → 330

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:308 → 330

zf-C2H2; Zinc finger, C2H2 type

pfam11914
Location:399 → 484

DUF3432; Domain of unknown function (DUF3432)

pfam11928
Location:106 → 181

DUF3446; Domain of unknown function (DUF3446)

pfam13465
Location:350 → 375

zf-H2C2_2; Zinc-finger double domain