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ext1.S exostosin glycosyltransferase 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399115, updated on 4-Nov-2024

Summary

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Official Symbol
ext1.S
Official Full Name
exostosin glycosyltransferase 1 S homeolog
Primary source
Xenbase:XB-GENE-867536
Locus tag
XELAEV_18033963mg
See related
EnsemblRapid:ENSXLAG00005021965 AllianceGenome:Xenbase:XB-GENE-867536
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ext1; xext1
Summary
Predicted to enable N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Predicted to act upstream of or within heparan sulfate proteoglycan biosynthetic process and protein glycosylation. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in chondrosarcoma and hereditary multiple exostoses. Orthologous to human EXT1 (exostosin glycosyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See ext1.S in Genome Data Viewer
Location:
chromosome: 6S
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6S NC_054382.1 (123249666..123433066, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6S NC_030735.1 (114584936..114768821, complement)

Chromosome 6S - NC_054382.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 30 S homeolog Neighboring gene uncharacterized LOC121395268 Neighboring gene sterile alpha motif domain containing 12 S homeolog Neighboring gene protein phosphatase 1 regulatory subunit 16A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cDNA cloning and distribution of XEXT1, the Xenopus homologue of EXT1. Katada T, et al. Dev Genes Evol, 2002 Jun. PMID 12070615
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
exostosin glycosyltransferase 1 S homeolog
Names
exostoses (multiple) 1
exostosin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090313.1 → NP_001083782.1  exostosin glycosyltransferase 1 S homeolog

    See identical proteins and their annotated locations for NP_001083782.1

    Status: PROVISIONAL

    Source sequence(s)
    BC094398
    UniProtKB/TrEMBL
    A0A974HEG3, Q52KD9
    Related
    ENSXLAP00005064618.1, ENSXLAT00005066132.1
    Conserved Domains (2) summary
    pfam03016
    Location:102 → 388
    Exostosin; Exostosin family
    pfam09258
    Location:472 → 713
    Glyco_transf_64; Glycosyl transferase family 64 domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    123249666..123433066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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