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npr1.L natriuretic peptide receptor 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399070, updated on 4-Nov-2024

Summary

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Official Symbol
npr1.L
Official Full Name
natriuretic peptide receptor 1 L homeolog
Primary source
Xenbase:XB-GENE-970525
Locus tag
XELAEV_18040863mg
See related
EnsemblRapid:ENSXLAG00005003266 AllianceGenome:Xenbase:XB-GENE-970525
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
npr1; npra; npr-1; npr-a; xgc-1
Summary
Predicted to enable several functions, including ATP binding activity; natriuretic peptide receptor activity; and phosphorus-oxygen lyase activity. Acts upstream of or within heart development. Predicted to be located in plasma membrane. Is expressed in musculoskeletal system and pharyngeal arch. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See npr1.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
22
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (133332531..133364444)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (118097392..118129763)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene SNAP-associated protein L homeolog Neighboring gene interleukin enhancer binding factor 2 L homeolog Neighboring gene integrator complex subunit 3 L homeolog Neighboring gene solute carrier family 27 member 3 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor. Devotta A, et al. Elife, 2023 May 10. PMID 37162198, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC68769

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables natriuretic peptide receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart development EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
natriuretic peptide receptor 1 L homeolog
Names
guanylyl cyclase
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090234.1 → NP_001083703.1  natriuretic peptide receptor 1 L homeolog precursor

    See identical proteins and their annotated locations for NP_001083703.1

    Status: PROVISIONAL

    Source sequence(s)
    BC063739
    UniProtKB/TrEMBL
    A0A974CAJ2, Q6P409
    Related
    ENSXLAP00005009699.1, ENSXLAT00005009855.1
    Conserved Domains (7) summary
    cd06385
    Location:30 → 437
    PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
    smart00044
    Location:835 → 1020
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:528 → 802
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:862 → 1048
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:48 → 408
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:811 → 856
    HNOBA; Heme NO binding associated
    pfam07714
    Location:541 → 796
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    133332531..133364444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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