prex1.L phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: prex1.L
Official Full Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 L homeolog
Primary source: Xenbase:XB-GENE-982965
See related: EnsemblRapid:ENSXLAG00005036715 AllianceGenome:Xenbase:XB-GENE-982965
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: prex1
Summary: Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within several processes, including G protein-coupled receptor signaling pathway; intracellular signal transduction; and positive regulation of GTPase activity. Predicted to be located in plasma membrane. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (9987673..10146946, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (9543342..9605456)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090233.1 → NP_001083702.1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 L homeolog

See identical proteins and their annotated locations for NP_001083702.1

Status: PROVISIONAL

Source sequence(s)

BC063738

UniProtKB/TrEMBL

A0A974H0B2, Q6P410

Related

ENSXLAP00005110081.1, ENSXLAT00005112291.1

Conserved Domains (7) summary

smart00228
Location:597 → 675

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:681 → 742

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04439
Location:387 → 467

DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...

cd04440
Location:479 → 571

DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...

cd01224
Location:219 → 370

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

pfam00169
Location:258 → 360

PH; PH domain

pfam00621
Location:28 → 214

RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

9987673..10146946 complement

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GenBank, FASTA, Sequence Viewer (Graphics)