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arnt.S aryl hydrocarbon receptor nuclear translocator S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399025, updated on 4-Nov-2024

Summary

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Official Symbol
arnt.S
Official Full Name
aryl hydrocarbon receptor nuclear translocator S homeolog
Primary source
Xenbase:XB-GENE-866594
Locus tag
XELAEV_18042715mg
See related
EnsemblRapid:ENSXLAG00005021013 AllianceGenome:Xenbase:XB-GENE-866594
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
arnt; arnt1; xArnt; arnt.2; hif1beta
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of aryl hydrocarbon receptor complex and transcription regulator complex. Is expressed in anatomical system; mesenchyme; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human ARNT (aryl hydrocarbon receptor nuclear translocator). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See arnt.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
24
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (94877079..94918636, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (90032083..90072514, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene cathepsin S Neighboring gene cathepsin S Neighboring gene cortexin domain-containing 1-like Neighboring gene SET domain bifurcated 1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC68805

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of aryl hydrocarbon receptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aryl hydrocarbon receptor nuclear translocator S homeolog
Names
aryl hydrocarbon receptor nuclear translocator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090153.1 → NP_001083622.1  aryl hydrocarbon receptor nuclear translocator S homeolog

    See identical proteins and their annotated locations for NP_001083622.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061940
    UniProtKB/TrEMBL
    A0A974H8Z2, Q6P6Z6
    Related
    ENSXLAP00005061663.1, ENSXLAT00005063116.1
    Conserved Domains (5) summary
    smart00091
    Location:146 → 210
    PAS; PAS domain
    cd00130
    Location:341 → 438
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:71 → 123
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:143 → 249
    PAS; PAS fold
    pfam14598
    Location:342 → 442
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    94877079..94918636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574145.1 → XP_041430079.1  aryl hydrocarbon receptor nuclear translocator S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1LLQ7, A0A974H8Z2
    Conserved Domains (3) summary
    smart00091
    Location:161 → 225
    PAS; PAS domain
    pfam08447
    Location:368 → 456
    PAS_3; PAS fold
    cd18947
    Location:81 → 145
    bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

  2. XM_041574146.1 → XP_041430080.1  aryl hydrocarbon receptor nuclear translocator S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1LMY8, A0A974H8Z2
    Conserved Domains (3) summary
    smart00091
    Location:161 → 225
    PAS; PAS domain
    pfam08447
    Location:368 → 456
    PAS_3; PAS fold
    cd18947
    Location:81 → 145
    bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

  3. XM_041574147.1 → XP_041430081.1  aryl hydrocarbon receptor nuclear translocator S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A1L8F4F7, A0A974C5U8, A0A974H8Z2
    Conserved Domains (3) summary
    cd18947
    Location:66 → 130
    bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
    pfam00989
    Location:143 → 249
    PAS; PAS fold
    pfam14598
    Location:342 → 442
    PAS_11; PAS domain

  4. XM_018231920.2 → XP_018087409.1  aryl hydrocarbon receptor nuclear translocator S homeolog isoform X4

    UniProtKB/TrEMBL
    A0A8J0TL17, A0A974H8Z2
Nucleotide Protein Strain
Heading Accession and Version

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