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plat.L plasminogen activator, tissue L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399010, updated on 4-Nov-2024

Summary

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Official Symbol
plat.L
Official Full Name
plasminogen activator, tissue L homeolog
Primary source
Xenbase:XB-GENE-1010823
Locus tag
XELAEV_18018790mg
See related
EnsemblRapid:ENSXLAG00005004151 AllianceGenome:Xenbase:XB-GENE-1010823
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
plat; t-pa
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within plasminogen activation; platelet-derived growth factor receptor signaling pathway; and smooth muscle cell migration. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and von Willebrand's disease 1. Orthologous to human PLAT (plasminogen activator, tissue type). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See plat.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
17
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (139859599..139889747, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (123683429..123747725, complement)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 6A L homeolog Neighboring gene adaptor related protein complex 3 subunit mu 2 L homeolog Neighboring gene inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog Neighboring gene voltage-dependent anion channel 3 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within plasminogen activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tissue-type plasminogen activator
Names
tissue plasminogen activator
NP_001083592.1
XP_018106335.1
XP_018106338.1
XP_041440949.1
XP_041440950.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090123.1 → NP_001083592.1  tissue-type plasminogen activator precursor

    See identical proteins and their annotated locations for NP_001083592.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061654
    UniProtKB/TrEMBL
    Q2PDK2, Q6P7I9
    Related
    ENSXLAP00005012404.1, ENSXLAT00005012582.1
    Conserved Domains (4) summary
    smart00020
    Location:301 → 541
    Tryp_SPc; Trypsin-like serine protease
    cd00108
    Location:117 → 201
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:304 → 544
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:206 → 287
    Kringle; Kringle domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    139859599..139889747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041585016.1 → XP_041440950.1  tissue-type plasminogen activator isoform X2

    UniProtKB/TrEMBL
    A0A1L8H251, A0A974DDN1, Q2PDK2
    Related
    ENSXLAP00005012412.1, ENSXLAT00005012590.1
    Conserved Domains (3) summary
    cd00108
    Location:130 → 214
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:317 → 557
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:219 → 300
    Kringle; Kringle domain

  2. XM_041585015.1 → XP_041440949.1  tissue-type plasminogen activator isoform X2

    UniProtKB/TrEMBL
    A0A1L8H251, A0A974DDN1, Q2PDK2
    Related
    ENSXLAP00005012406.1, ENSXLAT00005012585.1
    Conserved Domains (3) summary
    cd00108
    Location:130 → 214
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:317 → 557
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:219 → 300
    Kringle; Kringle domain

  3. XM_018250846.2 → XP_018106335.1  tissue-type plasminogen activator isoform X1

    UniProtKB/TrEMBL
    A0A8J0URA6, Q2PDK2
    Related
    ENSXLAP00005012411.1, ENSXLAT00005012589.1

  4. XM_018250849.2 → XP_018106338.1  tissue-type plasminogen activator isoform X3

    UniProtKB/TrEMBL
    A0A8J0UND0, Q2PDK2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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