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stk4.S serine/threonine kinase 4 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398925, updated on 4-Nov-2024

Summary

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Official Symbol
stk4.S
Official Full Name
serine/threonine kinase 4 S homeolog
Primary source
Xenbase:XB-GENE-955926
Locus tag
XELAEV_18046001mg
See related
EnsemblRapid:ENSXLAG00005023636 AllianceGenome:Xenbase:XB-GENE-955926
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
krs2; mst1; stk4; ysk3
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to act upstream of or within apoptotic process and hippo signaling. Predicted to be located in cytoplasm and nucleus. Is expressed in ectoderm; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human STK4 (serine/threonine kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See stk4.S in Genome Data Viewer
Location:
chromosome: 9_10S
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (3570264..3590014)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (3439884..3459630)

Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta S homeolog Neighboring gene poly(A) binding protein, cytoplasmic 1-like S homeolog Neighboring gene potassium voltage-gated channel, modifier subfamily S, member 1 S homeolog Neighboring gene matrilin 4 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC68762

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein tetramerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 4
NP_001083437.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089968.1 → NP_001083437.1  serine/threonine-protein kinase 4

    See identical proteins and their annotated locations for NP_001083437.1

    Status: PROVISIONAL

    Source sequence(s)
    BC060493
    UniProtKB/Swiss-Prot
    Q6PA14
    UniProtKB/TrEMBL
    A0A974BSQ5
    Related
    ENSXLAP00005069956.1, ENSXLAT00005071491.1
    Conserved Domains (3) summary
    cd06612
    Location:26 → 281
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:30 → 281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:431 → 478
    Mst1_SARAH; C terminal SARAH domain of Mst1

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    3570264..3590014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PA14.1 GenPept UniProtKB/Swiss-Prot:Q6PA14

Gene LinkOut

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