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akr1b1.S aldo-keto reductase family 1, member B1 (aldose reductase) S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398904, updated on 4-Nov-2024

Summary

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Official Symbol
akr1b1.S
Official Full Name
aldo-keto reductase family 1, member B1 (aldose reductase) S homeolog
Primary source
Xenbase:XB-GENE-5821808
Locus tag
XELAEV_18019824mg
See related
EnsemblRapid:ENSXLAG00005000614 AllianceGenome:Xenbase:XB-GENE-5821808
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
akr1b1; akr1b7
Summary
Predicted to enable aldose reductase (NADPH) activity. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See akr1b1.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (4481453..4492052, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (4490658..4501494, complement)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene achaete-scute homolog 4 Neighboring gene PR domain 4 S homeolog Neighboring gene putative uncharacterized protein DDB_G0287113 Neighboring gene aldo-keto reductase family 1, member C8 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC68609

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1, member B1 (aldose reductase) S homeolog
NP_001083398.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089929.1 → NP_001083398.1  aldo-keto reductase family 1, member B1 (aldose reductase) S homeolog

    See identical proteins and their annotated locations for NP_001083398.1

    Status: PROVISIONAL

    Source sequence(s)
    BC060383
    UniProtKB/TrEMBL
    A0A974D8L2, Q6PAB5
    Related
    ENSXLAP00005001722.1, ENSXLAT00005001763.1
    Conserved Domains (2) summary
    COG0656
    Location:4 → 299
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:11 → 291
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    4481453..4492052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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