polr2b.S polymerase (RNA) II (DNA directed) polypeptide B, 140kDa S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: polr2b.S
Official Full Name: polymerase (RNA) II (DNA directed) polypeptide B, 140kDa S homeolog
Primary source: Xenbase:XB-GENE-1012879
Locus tag: XELAEV_180096081mg
See related: EnsemblRapid:ENSXLAG00005019572 AllianceGenome:Xenbase:XB-GENE-1012879
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: polr2b
Summary: Predicted to enable several functions, including RNA polymerase II activity; metal ion binding activity; and ribonucleoside binding activity. Predicted to act upstream of or within DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Orthologous to human POLR2B (RNA polymerase II subunit B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1S

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (81637207..81748656)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (76520337..76617434)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II, core complex	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: polymerase (RNA) II (DNA directed) polypeptide B, 140kDa S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089903.1 → NP_001083372.1 polymerase (RNA) II (DNA directed) polypeptide B, 140kDa S homeolog

See identical proteins and their annotated locations for NP_001083372.1

Status: PROVISIONAL

Source sequence(s)

BC060458

UniProtKB/TrEMBL

Q6PA46

Related

ENSXLAP00005057454.1, ENSXLAT00005058808.1

Conserved Domains (4) summary

cd00653
Location:39 → 923

RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...

pfam04563
Location:38 → 441

RNA_pol_Rpb2_1; RNA polymerase beta subunit

pfam04566
Location:567 → 629

RNA_pol_Rpb2_4; RNA polymerase Rpb2, domain 4

pfam04567
Location:653 → 700

RNA_pol_Rpb2_5; RNA polymerase Rpb2, domain 5