brap.S BRCA1 associated protein S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: brap.S
Official Full Name: BRCA1 associated protein S homeolog
Primary source: Xenbase:XB-GENE-866103
Locus tag: XELAEV_18010660mg
See related: EnsemblRapid:ENSXLAG00005008679 AllianceGenome:Xenbase:XB-GENE-866103
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: imp; brap
Summary: Predicted to enable nucleic acid binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to act upstream of or within Ras protein signal transduction and protein ubiquitination. Predicted to be located in cytoplasm. Orthologous to human BRAP (BRCA1 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1S

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (151179463..151207782)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (135403134..135431419)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BRCA1 associated protein S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089891.1 → NP_001083360.1 BRCA1 associated protein S homeolog

See identical proteins and their annotated locations for NP_001083360.1

Status: PROVISIONAL

Source sequence(s)

BC060490

UniProtKB/TrEMBL

A0A974DUW9, Q6PA16

Related

ENSXLAP00005025201.1, ENSXLAT00005025910.1

Conserved Domains (4) summary

cd00162
Location:261 → 302

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd12718
Location:158 → 241

RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)

pfam02148
Location:315 → 377

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl23720
Location:449 → 533

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

151179463..151207782

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041574015.1 → XP_041429949.1 BRCA1 associated protein S homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1LLD0, A0A974DUW9

Conserved Domains (2) summary

smart00290
Location:314 → 363

ZnF_UBP; Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger

cd16457
Location:260 → 303

RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins