U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

alas1.L 5'-aminolevulinate synthase 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398824, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
alas1.L
Official Full Name
5'-aminolevulinate synthase 1 L homeolog
Primary source
Xenbase:XB-GENE-17343344
Locus tag
XELAEV_18023892mg
See related
EnsemblRapid:ENSXLAG00005026605 AllianceGenome:Xenbase:XB-GENE-17343344
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to enable 5-aminolevulinate synthase activity and pyridoxal phosphate binding activity. Predicted to act upstream of or within erythrocyte development; hemoglobin biosynthetic process; and protoporphyrinogen IX biosynthetic process. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Is expressed in ectoderm. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See alas1.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (127982308..128009812)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (122748202..122775719)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 7 L homeolog Neighboring gene POC1 centriolar protein A L homeolog Neighboring gene BLOC-1 related complex subunit 6 L homeolog Neighboring gene BRICK1, SCAR/WAVE actin-nucleating complex subunit L homeolog Neighboring gene protein interacting with PRKCA 1 L homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The phylogenetic relationship of tetrapod, coelacanth, and lungfish revealed by the sequences of forty-four nuclear genes. Takezaki N, et al. Mol Biol Evol, 2004 Aug. PMID 15128875
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC68700

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables 5-aminolevulinate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within erythrocyte development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemoglobin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within porphyrin-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein LOC398824
Names
aminolevulinic acid synthase 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089777.1 → NP_001083246.1  uncharacterized protein LOC398824

    See identical proteins and their annotated locations for NP_001083246.1

    Status: PREDICTED

    Source sequence(s)
    BC059988
    UniProtKB/TrEMBL
    A0A974D7E1, Q6PAZ6
    Related
    ENSXLAP00005079124.1, ENSXLAT00005080716.1
    Conserved Domains (3) summary
    COG0156
    Location:178 → 569
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    pfam09029
    Location:3 → 127
    Preseq_ALAS; 5-aminolevulinate synthase presequence
    cl18945
    Location:178 → 583
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    127982308..128009812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials