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usp16.L ubiquitin specific peptidase 16 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398823, updated on 4-Nov-2024

Summary

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Official Symbol
usp16.L
Official Full Name
ubiquitin specific peptidase 16 L homeolog
Primary source
Xenbase:XB-GENE-1007170
Locus tag
XELAEV_18011526mg
See related
EnsemblRapid:ENSXLAG00005027001 AllianceGenome:Xenbase:XB-GENE-1007170
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
usp16
Summary
Predicted to enable several functions, including cysteine-type peptidase activity; transcription coactivator activity; and zinc ion binding activity. Acts upstream of or within anterior/posterior pattern specification. Predicted to be located in nucleus. Orthologous to human USP16 (ubiquitin specific peptidase 16). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See usp16.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (16249221..16273181, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (16046549..16070792, complement)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene MAP3K7 C-terminal like L homeolog Neighboring gene chaperonin containing TCP1 subunit 8 L homeolog Neighboring gene uncharacterized LOC121399818 Neighboring gene RWD domain containing 2B L homeolog Neighboring gene sigma intracellular receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis. Zhuo X, et al. J Cell Biol, 2015 Aug 31. PMID 26323689, Free PMC Article
  2. Regulation of cell cycle progression and gene expression by H2A deubiquitination. Joo HY, et al. Nature, 2007 Oct 25. PMID 17914355
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC68701

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein homotetramerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 16
Names
ubiquitin thiolesterase 16
NP_001083244.1
XP_018100393.1
XP_018100394.1
XP_018100395.1
XP_018100396.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089775.1 → NP_001083244.1  ubiquitin carboxyl-terminal hydrolase 16

    See identical proteins and their annotated locations for NP_001083244.1

    Status: PROVISIONAL

    Source sequence(s)
    BC060022
    UniProtKB/Swiss-Prot
    Q6PAW2
    Related
    ENSXLAP00005080721.1, ENSXLAT00005082314.1
    Conserved Domains (3) summary
    cd02667
    Location:700 → 898
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:683 → 897
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:61 → 120
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    16249221..16273181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018244907.2 → XP_018100396.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X3

    UniProtKB/TrEMBL
    A0A8J0UBQ7
    Related
    ENSXLAP00005080277.1, ENSXLAT00005081870.1

  2. XM_018244906.2 → XP_018100395.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X2

    UniProtKB/TrEMBL
    A0A8J0UEE2

  3. XM_018244904.2 → XP_018100393.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X1

    UniProtKB/TrEMBL
    A0A1L8HCR0, A0A974DMG3

  4. XM_018244905.2 → XP_018100394.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X1

    UniProtKB/TrEMBL
    A0A1L8HCR0, A0A974DMG3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PAW2.1 GenPept UniProtKB/Swiss-Prot:Q6PAW2

Gene LinkOut

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