dgat2.L diacylglycerol O-acyltransferase 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: dgat2.L
Official Full Name: diacylglycerol O-acyltransferase 2 L homeolog
Primary source: Xenbase:XB-GENE-6078761
Locus tag: XELAEV_18014067mg
See related: EnsemblRapid:ENSXLAG00005013507 AllianceGenome:Xenbase:XB-GENE-6078761
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ARAT; dgat2
Summary: Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to act upstream of or within diacylglycerol biosynthetic process; monoacylglycerol biosynthetic process; and triglyceride biosynthetic process. Predicted to be located in lipid droplet and perinuclear endoplasmic reticulum membrane. Is expressed in dermal system; ectoderm; genital system; nervous system; and visual system. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (185611575..185626225, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (178704888..178719519)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables retinol O-fatty-acyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within diacylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within diacylglycerol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycerol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoacylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: diacylglycerol O-acyltransferase 2

Names: acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol O-acyltransferase homolog 2; diglyceride acyltransferase 2; retinol O-fatty-acyltransferase

NP_001083204.1

EC 2.3.1.20

EC 2.3.1.76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089735.1 → NP_001083204.1 diacylglycerol O-acyltransferase 2

See identical proteins and their annotated locations for NP_001083204.1

Status: PROVISIONAL

Source sequence(s)

BC059991

UniProtKB/Swiss-Prot

Q6PAZ3

UniProtKB/TrEMBL

A0A974DRY4

Related

ENSXLAP00005039844.1, ENSXLAT00005040765.1

Conserved Domains (1) summary

pfam03982
Location:66 → 360

DAGAT; Diacylglycerol acyltransferase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

185611575..185626225 complement

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GenBank, FASTA, Sequence Viewer (Graphics)