ppia.L peptidylprolyl isomerase A (cyclophilin A) L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ppia.L
Official Full Name: peptidylprolyl isomerase A (cyclophilin A) L homeolog
Primary source: Xenbase:XB-GENE-5778505
Locus tag: XELAEV_18018631mg
See related: EnsemblRapid:ENSXLAG00005002999 AllianceGenome:Xenbase:XB-GENE-5778505
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: CYBP; cyp7; cypa; cyph; ppia
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to act upstream of or within apoptotic process; protein folding; and protein peptidyl-prolyl isomerization. Predicted to be located in cytoplasm; extracellular region; and nucleus. Is expressed in ectoderm; musculoskeletal system; nervous system; pharyngeal arch; and urinary system. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3L

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (134178785..134186103, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (118840142..118847464, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Over-expression leads to an expansion and disorganisation of the neural crest domain.
Title: Cloning and characterisation of the immunophilin X-CypA in Xenopus laevis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidylprolyl isomerase A (cyclophilin A) L homeolog

Names: cyclophilin A; immunophilin; ppiase A; rotamase A

NP_001082659.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089190.1 → NP_001082659.1 peptidylprolyl isomerase A (cyclophilin A) L homeolog

See identical proteins and their annotated locations for NP_001082659.1

Status: PROVISIONAL

Source sequence(s)

AY646834

UniProtKB/TrEMBL

Q6DTN6, Q6NUH4

Related

ENSXLAP00005008962.1, ENSXLAT00005009088.1

Conserved Domains (1) summary

cd01926
Location:4 → 162

cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

134178785..134186103 complement

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GenBank, FASTA, Sequence Viewer (Graphics)