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best2.S bestrophin 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398601, updated on 4-Nov-2024

Summary

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Official Symbol
best2.S
Official Full Name
bestrophin 2 S homeolog
Primary source
Xenbase:XB-GENE-6255790
Locus tag
XELAEV_18000802mg
See related
EnsemblRapid:ENSXLAG00005011295 AllianceGenome:Xenbase:XB-GENE-6255790
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
vmd2l1; best2-a; best2-b; variant 2
Summary
Predicted to enable chloride channel activity. Predicted to act upstream of or within chloride transport and monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human BEST2 (bestrophin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See best2.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (125326610..125334226, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694811.1 (1839434..1847319, complement)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene jun B proto-oncogene S homeolog Neighboring gene protein Hook homolog 2-like Neighboring gene calcium channel, voltage-dependent, P/Q type, alpha 1A subunit S homeolog Neighboring gene immediate early response 2 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two bestrophins cloned from Xenopus laevis oocytes express Ca(2+)-activated Cl(-) currents. Qu Z, et al. J Biol Chem, 2003 Dec 5. PMID 12939260
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC81437

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bestrophin 2 S homeolog
Names
bestrophin-2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089140.1 → NP_001082609.1  bestrophin 2 S homeolog

    See identical proteins and their annotated locations for NP_001082609.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084229
    UniProtKB/TrEMBL
    Q5XH45, Q7ZZK4
    Related
    ENSXLAP00005033168.1, ENSXLAT00005033962.1
    Conserved Domains (1) summary
    pfam01062
    Location:8 → 314
    Bestrophin; Bestrophin, RFP-TM, chloride channel

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    125326610..125334226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials