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rad9a.L RAD9 checkpoint clamp component A L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398594, updated on 4-Nov-2024

Summary

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Official Symbol
rad9a.L
Official Full Name
RAD9 checkpoint clamp component A L homeolog
Primary source
Xenbase:XB-GENE-975078
Locus tag
XELAEV_18035119mg
See related
EnsemblRapid:ENSXLAG00005031464 AllianceGenome:Xenbase:XB-GENE-975078
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
rad9; XRad9; rad9a
Summary
Predicted to act upstream of or within DNA integrity checkpoint signaling; DNA repair; and cellular response to ionizing radiation. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD9A (RAD9 checkpoint clamp component A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rad9a.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (63604688..63643475, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (55484766..55521931, complement)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene carnosine synthase 1 L homeolog Neighboring gene uncharacterized LOC121395521 Neighboring gene post-GPI attachment to proteins GalNAc transferase 4 L homeolog Neighboring gene ring finger protein 20 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus. Jones RE, et al. Mol Biol Cell, 2003 Sep. PMID 12972573, Free PMC Article
  2. Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks. Lee J, et al. Mol Biol Cell, 2010 Mar 15. PMID 20110345, Free PMC Article
  3. TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks. Yan S, et al. J Cell Biol, 2009 Mar 23. PMID 19289795, Free PMC Article
  4. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. Lee J, et al. J Biol Chem, 2007 Sep 21. PMID 17636252
  5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Rad17 mediates the interaction of the Rad9-Hus1-Rad1 (9-1-1) complex with the ATR-activating protein TopBP1 in Xenopus egg extracts.
    Title: Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks.
  2. TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex (rad9-rad1-Hus1) to stalled DNA replication forks.
    Title: TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.
  3. interaction of the 9-1-1 complex (Rad9-Hus1-Rad1) with the BRCT I-II region of TopBP1 is necessary for binding of ATR-ATRIP to the ATR-activating domain of TopBP1 and the ensuing activation of ATR
    Title: The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC85563

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of checkpoint clamp complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RAD9 checkpoint clamp component A L homeolog
Names
PCNA-like DNA checkpoint protein Rad9
RAD9 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089131.2 → NP_001082600.1  RAD9 checkpoint clamp component A L homeolog

    See identical proteins and their annotated locations for NP_001082600.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084872
    UniProtKB/TrEMBL
    A0A974HBS1, Q7ZZU5
    Related
    ENSXLAP00005094265.1, ENSXLAT00005095967.1
    Conserved Domains (1) summary
    pfam04139
    Location:17 → 265
    Rad9

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    63604688..63643475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041568427.1 → XP_041424361.1  RAD9 checkpoint clamp component A L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A974HBS1, Q7ZZU5
    Conserved Domains (1) summary
    pfam04139
    Location:17 → 265
    Rad9

  2. XM_018224364.2 → XP_018079853.1  RAD9 checkpoint clamp component A L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0SZ53
    Related
    ENSXLAP00005094403.1, ENSXLAT00005096105.1

  3. XM_018224365.2 → XP_018079854.1  RAD9 checkpoint clamp component A L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A974HBS1, Q7ZZU5
    Conserved Domains (1) summary
    pfam04139
    Location:17 → 265
    Rad9

  4. XM_041568425.1 → XP_041424359.1  RAD9 checkpoint clamp component A L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A974HBS1, Q7ZZU5
    Conserved Domains (1) summary
    pfam04139
    Location:17 → 265
    Rad9

  5. XM_041568426.1 → XP_041424360.1  RAD9 checkpoint clamp component A L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A974HBS1, Q7ZZU5
    Conserved Domains (1) summary
    pfam04139
    Location:17 → 265
    Rad9

  6. XM_018224369.2 → XP_018079858.1  RAD9 checkpoint clamp component A L homeolog isoform X4

    UniProtKB/TrEMBL
    A0A8J0T951

  7. XM_018224368.2 → XP_018079857.1  RAD9 checkpoint clamp component A L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J0T877

RNA

  1. XR_001932160.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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