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iqgap2.S IQ motif containing GTPase activating protein 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398588, updated on 18-Sep-2024

Summary

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Official Symbol
iqgap2.S
Official Full Name
IQ motif containing GTPase activating protein 2 S homeolog
Primary source
Xenbase:XB-GENE-5752029
Locus tag
XELAEV_18010897mg
See related
EnsemblRapid:ENSXLAG00005033865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
iqgap2; xiqgap2
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Genomic context

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See iqgap2.S in Genome Data Viewer
Location:
chromosome: 1S
Exon count:
41
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (172859512..173040320)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (156867495..157048501)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121399515 Neighboring gene uncharacterized LOC108707266 Neighboring gene coagulation factor II (thrombin) receptor-like 2 S homeolog Neighboring gene coagulation factor 2 (thrombin) receptor S homeolog Neighboring gene coagulation factor 2 (thrombin) receptor-like 1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos. Yamashiro S, et al. Dev Biol, 2007 Aug 15. PMID 17617398
  2. Localization of two IQGAPs in cultured cells and early embryos of Xenopus laevis. Yamashiro S, et al. Cell Motil Cytoskeleton, 2003 May. PMID 12673597

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suppression of XIQGAP2 expression caused ectodermal lesions in the neurula stage embryos.
    Title: IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mitotic actomyosin contractile ring assembly actin filament organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane bounded cell projection IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IQ motif containing GTPase activating protein 2 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089119.2 → NP_001082588.1  IQ motif containing GTPase activating protein 2 S homeolog

    See identical proteins and their annotated locations for NP_001082588.1

    Status: VALIDATED

    Source sequence(s)
    AB093561
    UniProtKB/TrEMBL
    A0A974DVN6, Q7ZT76
    Related
    ENSXLAP00005102139.1, ENSXLAT00005104130.1
    Conserved Domains (7) summary
    smart00015
    Location:772 → 793
    IQ; Calmodulin-binding motif
    smart00456
    Location:683 → 710
    WW; Domain with 2 conserved Trp (W) residues
    cd05131
    Location:999 → 1357
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:988 → 1312
    RasGAP; GTPase-activator protein for Ras-like GTPases
    COG5199
    Location:45 → 207
    SCP1; Calponin [Cytoskeleton]
    cd00014
    Location:42 → 154
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam03836
    Location:1450 → 1583
    RasGAP_C; RasGAP C-terminus

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    172859512..173040320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041573942.1 → XP_041429876.1  IQ motif containing GTPase activating protein 2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1LKS4, A0A974DVN6
    Related
    ENSXLAP00005102342.1, ENSXLAT00005104337.1
    Conserved Domains (4) summary
    smart00015
    Location:773 → 794
    IQ; Calmodulin-binding motif
    smart00456
    Location:684 → 711
    WW; Domain with 2 conserved Trp (W) residues
    cd05131
    Location:1000 → 1358
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    COG5261
    Location:856 → 1661
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

  2. XM_041573949.1 → XP_041429883.1  IQ motif containing GTPase activating protein 2 S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1LJX2, A0A974DVN6
    Related
    ENSXLAP00005102250.1, ENSXLAT00005104245.1
    Conserved Domains (4) summary
    smart00015
    Location:689 → 710
    IQ; Calmodulin-binding motif
    smart00456
    Location:600 → 627
    WW; Domain with 2 conserved Trp (W) residues
    cd05131
    Location:916 → 1274
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    COG5261
    Location:772 → 1577
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

  3. XM_041573945.1 → XP_041429879.1  IQ motif containing GTPase activating protein 2 S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1LL72, A0A974DVN6
    Related
    ENSXLAP00005102048.1, ENSXLAT00005104039.1
    Conserved Domains (4) summary
    smart00015
    Location:746 → 767
    IQ; Calmodulin-binding motif
    smart00456
    Location:657 → 684
    WW; Domain with 2 conserved Trp (W) residues
    cd05131
    Location:973 → 1331
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    COG5261
    Location:829 → 1634
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version

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