atp1a1.S ATPase Na+/K+ transporting subunit alpha 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: atp1a1.S
Official Full Name: ATPase Na+/K+ transporting subunit alpha 1 S homeolog
Primary source: Xenbase:XB-GENE-865506
Locus tag: XELAEV_18014489mg
See related: EnsemblRapid:ENSXLAG00005025313 AllianceGenome:Xenbase:XB-GENE-865506
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: atp1a1; K-ATPase; atp1a1-a; atp1a1-b; Na+K+ATPase
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and P-type sodium:potassium-exchanging transporter activity. Predicted to act upstream of or within intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in urinary system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2S

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (29284072..29300810)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (28998370..29015108)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type sodium:potassium-exchanging transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular sodium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
part_of sodium:potassium-exchanging ATPase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATPase Na+/K+ transporting subunit alpha 1 S homeolog

Names: ATPase, Na+/K+ transporting, alpha 1 polypeptide S homeolog; Na+/K+ ATPase; Na+K+ ATPase; adenosine triphosphatase, sodium-potassium pump alpha1 subunit

NP_001082580.1

EC 7.2.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089111.1 → NP_001082580.1 ATPase Na+/K+ transporting subunit alpha 1 S homeolog

See identical proteins and their annotated locations for NP_001082580.1

Status: PROVISIONAL

Source sequence(s)

BC049006

UniProtKB/TrEMBL

Q6IP41, Q7ZSX5

Related

ENSXLAP00005075363.1, ENSXLAT00005076944.1

Conserved Domains (6) summary

smart00831
Location:41 → 114

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:606 → 752

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:32 → 1023

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:134 → 365

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:799 → 1008

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:427 → 521

Cation_ATPase; Cation transport ATPase (P-type)