rad17.L RAD17 checkpoint clamp loader component L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rad17.L
Official Full Name: RAD17 checkpoint clamp loader component L homeolog
Primary source: Xenbase:XB-GENE-1002360
Locus tag: XELAEV_18008122mg
See related: EnsemblRapid:ENSXLAG00005007718 AllianceGenome:Xenbase:XB-GENE-1002360
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rad17; Xrad17
Summary: Predicted to enable ATP binding activity; DNA clamp loader activity; and chromatin binding activity. Predicted to act upstream of or within DNA damage checkpoint signaling; DNA repair; and mitotic DNA replication checkpoint signaling. Predicted to be located in nucleus. Predicted to be part of Rad17 RFC-like complex. Orthologous to human RAD17 (RAD17 checkpoint clamp loader component). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (198409696..198430428, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (185290198..185310977, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Rad17 mediates the interaction of the Rad9-Hus1-Rad1 (9-1-1) complex with the ATR-activating protein TopBP1 in Xenopus egg extracts.
Title: Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic DNA replication checkpoint signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Rad17 RFC-like complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RAD17 checkpoint clamp loader component L homeolog

Names: RAD17 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089097.1 → NP_001082566.1 RAD17 checkpoint clamp loader component L homeolog

See identical proteins and their annotated locations for NP_001082566.1

Status: PROVISIONAL

Source sequence(s)

BC072343

UniProtKB/TrEMBL

A0A974E250, Q6INE0

Related

ENSXLAP00005022041.1, ENSXLAT00005022732.1

Conserved Domains (2) summary

TIGR00602
Location:14 → 646

rad24; checkpoint protein rad24

pfam13191
Location:106 → 252

AAA_16; AAA ATPase domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

198409696..198430428 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)