top2a.L DNA topoisomerase II alpha L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: top2a.L
Official Full Name: DNA topoisomerase II alpha L homeolog
Primary source: Xenbase:XB-GENE-970184
Locus tag: XELAEV_18043138mg
See related: EnsemblRapid:ENSXLAG00005036545 AllianceGenome:Xenbase:XB-GENE-970184
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: top2; tp2a; top2a
Summary: Predicted to enable several functions, including ATP binding activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and metal ion binding activity. Predicted to act upstream of or within chromosome organization; resolution of meiotic recombination intermediates; and rhythmic process. Predicted to be located in nucleolus and nucleoplasm. Is expressed in ectoderm; mesoderm; nervous system; and visual system. Orthologous to human TOP2A (DNA topoisomerase II alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (1566729..1589595)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (1535166..1558058)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Guiding functions of the C-terminal domain of topoisomerase IIalpha advance mitotic chromosome assembly.
Title: Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly.
Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination.
Title: Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination.
MRN (Mre11, Rad50, and Nbs1) complex, CtIP, and BRCA1 are required for both the removal of Top2-DNA adducts and the subsequent resection of Top2-adducted DSB ends.
Title: MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts.
TopoisomeraseIIalpha-C-terminal domain SUMOylation regulates the centromeric localization of Claspin.
Title: SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin.
Topo IIalpha clamps trapped by ICRF-193 during but not after nuclear assembly block replication because topo IIalpha acts on unreplicated DNA before S phase but behind the forks during S phase.
Title: DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts.
findings provide evidence for the regulation of TopoIIalpha activity on mitotic chromosomes by SUMOylation; propose a novel mechanism for regulation of centromeric DNA catenation during mitosis by PIASy-mediated SUMOylation of TopoIIalpha
Title: PIASy-dependent SUMOylation regulates DNA topoisomerase IIalpha activity.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase activity	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA topological change	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within resolution of meiotic recombination intermediates	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sister chromatid segregation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA topoisomerase II alpha L homeolog

Names: topo II; topo II alpha; topoisomerase (DNA) II alpha 170kDa; topoisomerase (DNA) II alpha L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089033.1 → NP_001082502.1 DNA topoisomerase II alpha L homeolog

See identical proteins and their annotated locations for NP_001082502.1

Status: PROVISIONAL

Source sequence(s)

BC072193

UniProtKB/TrEMBL

A0A974BW41, Q6INT0

Related

ENSXLAP00005109432.1, ENSXLAT00005111621.1

Conserved Domains (7) summary

cd03365
Location:453 → 573

TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...

cd00187
Location:709 → 1164

TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...

cd03481
Location:263 → 415

TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...

PTZ00108
Location:23 → 1373

PTZ00108; DNA topoisomerase 2-like protein; Provisional

pfam02518
Location:78 → 175

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

pfam08070
Location:1490 → 1571

DTHCT; DTHCT (NUC029) region

pfam16898
Location:571 → 709

TOPRIM_C; C-terminal associated domain of TOPRIM