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UQCR-C2 Ubiquinol-cytochrome c reductase core protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39846, updated on 4-Jul-2024

Summary

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Official Symbol
UQCR-C2provided by FlyBase
Official Full Name
Ubiquinol-cytochrome c reductase core protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0250814
Locus tag
Dmel_CG4169
See related
AllianceGenome:FB:FBgn0250814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey245; BEST:GH10978; CG 4169; CG4169; Dmel\CG4169; dUQCRC2; UCR2; UQCR-cp2; UQCRC2
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including embryonic Malpighian tubule; embryonic/larval muscle system; extended germ band embryo; gut section; and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See UQCR-C2 in Genome Data Viewer
Location:
73A10-73A10; 3-44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16584124..16586111)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16577224..16579211)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Regulatory particle non-ATPase 12 Neighboring gene antisense RNA:CR45895 Neighboring gene Syntaxin 8 Neighboring gene uncharacterized protein Neighboring gene lethal (3) 73Ah Neighboring gene transformer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modelling of BCS1L-related human mitochondrial disease in Drosophila melanogaster. Brischigliaro M, et al. J Mol Med (Berl), 2021 Oct. PMID 34274978, Free PMC Article
  2. Parkin expression reverses mitochondrial dysfunction in fused in sarcoma-induced amyotrophic lateral sclerosis. Cha SJ, et al. Insect Mol Biol, 2020 Feb. PMID 31290213
  3. Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. O'Hanlon ME, et al. Neurobiol Dis, 2022 Sep. PMID 35764292
  4. Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis. Pizzo L, et al. PLoS Genet, 2021 Apr. PMID 33819264, Free PMC Article
  5. Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in drosophila melanogaster. Zhang W, et al. BMC Bioinformatics, 2008 Feb 28. PMID 18307794, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, ubiquinol to cytochrome c ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of mitochondrial respiratory chain complex III ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ubiquinol-cytochrome c reductase core protein 2
Names
BEST:GH10978
CG4169-PA
CG4169-PB
UQCR-C2-PA
UQCR-C2-PB
Ubiquinol-cytochrome C reductase complex core protein 2
Ubiquinol-cytochrome c oxidoreductase core protein 2
ubiquinol-cytochrome c reductase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16584124..16586111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140648.2 → NP_648905.1  Ubiquinol-cytochrome c reductase core protein 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648905.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV75
    Related
    FBpp0075069
    Conserved Domains (3) summary
    COG0612
    Location:22 → 417
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    pfam00675
    Location:41 → 185
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:190 → 364
    Peptidase_M16_C; Peptidase M16 inactive domain

  2. NM_001275026.1 → NP_001261955.1  Ubiquinol-cytochrome c reductase core protein 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261955.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV75
    Conserved Domains (3) summary
    COG0612
    Location:22 → 417
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    pfam00675
    Location:41 → 185
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:190 → 364
    Peptidase_M16_C; Peptidase M16 inactive domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VV75 Q9VV75

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