c1qbp.S complement component 1, q subcomponent binding protein S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: c1qbp.S
Official Full Name: complement component 1, q subcomponent binding protein S homeolog
Primary source: Xenbase:XB-GENE-973235
Locus tag: XELAEV_18015438mg
See related: AllianceGenome:Xenbase:XB-GENE-973235
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: X38k; c1qbp
Summary: Predicted to enable complement component C1q complex binding activity; kininogen binding activity; and transcription corepressor activity. Predicted to act upstream of or within several processes, including cytosolic ribosome assembly; negative regulation of mRNA splicing, via spliceosome; and regulation of complement activation. Predicted to be located in several cellular components, including cell surface; mitochondrial matrix; and nucleus. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 33. Orthologous to human C1QBP (complement C1q binding protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2S

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (96567456..96575443, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (87546693..87554786, complement)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables complement component C1q complex binding	IEA Inferred from Electronic Annotation more info
enables kininogen binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytosolic ribosome assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of complement activation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: complement component 1, q subcomponent binding protein S homeolog

Names: 38k protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088909.1 → NP_001082378.1 complement component 1, q subcomponent binding protein S homeolog

See identical proteins and their annotated locations for NP_001082378.1

Status: PROVISIONAL

Source sequence(s)

BC056846

UniProtKB/TrEMBL

Q6PGS7

Conserved Domains (1) summary

pfam02330
Location:19 → 184

MAM33; Mitochondrial glycoprotein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

96567456..96575443 complement

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GenBank, FASTA, Sequence Viewer (Graphics)