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nuf2.L NDC80 kinetochore complex component NUF2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398428, updated on 17-Aug-2024

Summary

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Official Symbol
nuf2.L
Official Full Name
NDC80 kinetochore complex component NUF2 L homeolog
Primary source
Xenbase:XB-GENE-1001444
Locus tag
XELAEV_18023406mg
See related
EnsemblRapid:ENSXLAG00005012319
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
nuf2; cdca1; ct106; nuf2r; nuf2-a; nuf2-b; cdca1-a
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Genomic context

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See nuf2.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
15
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (104495221..104510787)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (99222082..99237504)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 4 L homeolog Neighboring gene regulator of G-protein signaling 5 L homeolog Neighboring gene pre-B-cell leukemia homeobox 1 L homeolog Neighboring gene LIM homeobox transcription factor 1 alpha L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore. Emanuele MJ, et al. Mol Biol Cell, 2005 Oct. PMID 16079178, Free PMC Article
  2. The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. McCleland ML, et al. Genes Dev, 2003 Jan 1. PMID 12514103, Free PMC Article
  3. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. McCleland ML, et al. Curr Biol, 2004 Jan 20. PMID 14738735
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within attachment of mitotic spindle microtubules to kinetochore IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kinetochore organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meiotic chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Ndc80 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ndc80 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinetochore protein Nuf2-A
Names
NUF2, NDC80 kinetochore complex component L homeolog
NUF2, NDC80 kinetochore complex component, homolog
cell division cycle-associated protein 1-A
kinetochore spindle checkpoint protein Nuf2
xNuf2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088901.1 → NP_001082370.1  kinetochore protein Nuf2-A

    See identical proteins and their annotated locations for NP_001082370.1

    Status: PROVISIONAL

    Source sequence(s)
    AY168014
    UniProtKB/Swiss-Prot
    Q8AWF4
    UniProtKB/TrEMBL
    A0A1L8GN20, A0A974D0S9, A0A974D6S4
    Conserved Domains (2) summary
    COG1196
    Location:143 → 455
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03800
    Location:3 → 146
    Nuf2; Nuf2 family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    104495221..104510787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018256546.2 → XP_018112035.1  kinetochore protein Nuf2-A isoform X1

    UniProtKB/Swiss-Prot
    Q8AWF4
    UniProtKB/TrEMBL
    A0A1L8GN20, A0A974D0S9, A0A974D6S4
    Related
    ENSXLAP00005036122.1, ENSXLAT00005037022.1
    Conserved Domains (2) summary
    COG1196
    Location:143 → 455
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03800
    Location:3 → 146
    Nuf2; Nuf2 family

  2. XM_041589211.1 → XP_041445145.1  kinetochore protein Nuf2-A isoform X1

    UniProtKB/Swiss-Prot
    Q8AWF4
    UniProtKB/TrEMBL
    A0A1L8GN20, A0A974D0S9, A0A974D6S4
    Related
    ENSXLAP00005036117.1, ENSXLAT00005037017.1
    Conserved Domains (2) summary
    COG1196
    Location:143 → 455
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03800
    Location:3 → 146
    Nuf2; Nuf2 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8AWF4.1 GenPept UniProtKB/Swiss-Prot:Q8AWF4

Gene LinkOut

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