pofut1.L protein O-fucosyltransferase 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pofut1.L
Official Full Name: protein O-fucosyltransferase 1 L homeolog
Primary source: Xenbase:XB-GENE-979250
Locus tag: XELAEV_18043053mg
See related: EnsemblRapid:ENSXLAG00005031288 AllianceGenome:Xenbase:XB-GENE-979250
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: fut12; o-fut; pofut1; o-fuc-t; o-fuct-1
Summary: Predicted to enable peptide-O-fucosyltransferase activity. Predicted to act upstream of or within several processes, including fucose metabolic process; protein O-linked fucosylation; and regulation of Notch signaling pathway. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Dowling-Degos disease. Orthologous to human POFUT1 (protein O-fucosyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (125876..132878, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (83684..90656, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables peptide-O-fucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein O-linked fucosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein O-fucosyltransferase 1 L homeolog

Names: putative protein-O-fucosyltransferase

NP_001082360.1

EC 2.4.1.221

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088891.1 → NP_001082360.1 protein O-fucosyltransferase 1 L homeolog precursor

See identical proteins and their annotated locations for NP_001082360.1

Status: PROVISIONAL

Source sequence(s)

BC106426

UniProtKB/TrEMBL

A0A974H1Y6, Q3B8H6

Related

ENSXLAP00005093671.1, ENSXLAT00005095369.1

Conserved Domains (2) summary

cd11302
Location:23 → 371

O-FucT-1; GDP-fucose protein O-fucosyltransferase 1

pfam10250
Location:32 → 364

O-FucT; GDP-fucose protein O-fucosyltransferase