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mbf1 multiprotein bridging factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39842, updated on 18-Sep-2024

Summary

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Official Symbol
mbf1provided by FlyBase
Official Full Name
multiprotein bridging factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0262732
Locus tag
Dmel_CG4143
See related
AllianceGenome:FB:FBgn0262732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH10148; BcDNA:GM01267; CG4143; Dmel\CG4143; Mbf-1; MBF-1; Mbf1; MBF1; MRE4
Summary
Enables mRNA binding activity; protein-macromolecule adaptor activity; and transcription coactivator activity. Involved in central nervous system development; open tracheal system development; and regulation of RNA metabolic process. Located in cytosol and nucleus. Is expressed in adult head; central nervous system; imaginal disc; organism; and testis. Orthologous to human EDF1 (endothelial differentiation related factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See mbf1 in Genome Data Viewer
Location:
73A9-73A9; 3-44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16574436..16576871)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16567536..16569971)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Multiple inositol polyphosphate phosphatase 1 Neighboring gene Ubiquinol-cytochrome c reductase 6.4 kDa subunit-like Neighboring gene nuclear RNA export factor 2 Neighboring gene pseudo Neighboring gene survival motor neuron

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila. Jindra M, et al. EMBO J, 2004 Sep 1. PMID 15306851, Free PMC Article
  2. Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila. Roignant JY, et al. RNA, 2003 Mar. PMID 12592004, Free PMC Article
  3. Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems. Liu QX, et al. Development, 2003 Feb. PMID 12506002
  4. Mbf1 ensures Polycomb silencing by protecting E(z) mRNA from degradation by Pacman. Nishioka K, et al. Development, 2018 Mar 9. PMID 29523653, Free PMC Article
  5. Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage in Drosophila melanogaster. Matsuoka S, et al. Genetics, 2017 Jun. PMID 28396508, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila Mbf1 associates with E(z) mRNA and protects it from degradation by the exoribonuclease Pacman (Pcm), thereby ensuring Polycomb silencing.
    Title: Mbf1 ensures Polycomb silencing by protecting E(z) mRNA from degradation by Pacman.
  2. These data demonstrate a crucial role of MBF1 in the development of tracheae and central nervous system
    Title: Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems.
  3. by preserving the redox-sensitive AP-1 activity, MBF1 provides an advantage during oxidative stress
    Title: Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in central nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in open tracheal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
multiprotein bridging factor 1
Names
CG4143-PA
CG4143-PB
CG4143-PC
CG4143-PD
CG4143-PE
mRNA-like ncRNA in embryogenesis 4
mbf1-PA
mbf1-PB
mbf1-PC
mbf1-PD
mbf1-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16574436..16576871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259867.1 → NP_001246796.1  multiprotein bridging factor 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246796.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XZ03
    Conserved Domains (2) summary
    cl26727
    Location:12 → 144
    aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
    pfam08523
    Location:3 → 69
    MBF1; Multiprotein bridging factor 1

  2. NM_168673.2 → NP_730178.1  multiprotein bridging factor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730178.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XZ03
    Related
    FBpp0075152
    Conserved Domains (2) summary
    cl26727
    Location:12 → 144
    aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
    pfam08523
    Location:3 → 69
    MBF1; Multiprotein bridging factor 1

  3. NM_001259866.1 → NP_001246795.1  multiprotein bridging factor 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246795.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XZ03
    Conserved Domains (2) summary
    cl26727
    Location:12 → 144
    aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
    pfam08523
    Location:3 → 69
    MBF1; Multiprotein bridging factor 1

  4. NM_079386.2 → NP_524110.1  multiprotein bridging factor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524110.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XZ03
    Related
    FBpp0075151
    Conserved Domains (2) summary
    cl26727
    Location:12 → 144
    aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
    pfam08523
    Location:3 → 69
    MBF1; Multiprotein bridging factor 1

  5. NM_001275023.1 → NP_001261952.1  multiprotein bridging factor 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261952.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFR6
    Conserved Domains (3) summary
    COG1813
    Location:12 → 144
    aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
    pfam01381
    Location:79 → 131
    HTH_3; Helix-turn-helix
    pfam08523
    Location:2 → 70
    MBF1; Multiprotein bridging factor 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFR6 M9PFR6
Q8MT00 Q8MT00
Q9XZ03 Q9XZ03

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