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plcg1.L phospholipase C gamma 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398359, updated on 4-Nov-2024

Summary

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Official Symbol
plcg1.L
Official Full Name
phospholipase C gamma 1 L homeolog
Primary source
Xenbase:XB-GENE-982499
Locus tag
XELAEV_18043918mg
See related
EnsemblRapid:ENSXLAG00005025689 AllianceGenome:Xenbase:XB-GENE-982499
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
plc1; plcg1; nckap3; plc-ii; plc148; plcgamma1
Summary
Predicted to enable calcium ion binding activity and phosphatidylinositol phospholipase C activity. Predicted to act upstream of or within several processes, including phosphatidylinositol-mediated signaling; positive regulation of epithelial cell migration; and release of sequestered calcium ion into cytosol. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human PLCG1 (phospholipase C gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See plcg1.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
33
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (42659031..42719211)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (32348457..32408753)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase I gene 1 L homeolog Neighboring gene transcription factor TBF1-like Neighboring gene zinc fingers and homeoboxes 3 L homeolog Neighboring gene RAB5 interacting factor L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipase C gamma 1 L homeolog
Names
PLC gamma 1
phospholipase C, gamma 1
phospholipase C-gamma-1b
NP_001082278.1
XP_018089659.1
XP_018089660.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088809.2 → NP_001082278.1  phospholipase C gamma 1 L homeolog

    See identical proteins and their annotated locations for NP_001082278.1

    Status: PROVISIONAL

    Source sequence(s)
    BC068831
    UniProtKB/TrEMBL
    A0A974GZH3, Q6NTX2
    Related
    ENSXLAP00005077017.1, ENSXLAT00005078608.1
    Conserved Domains (10) summary
    smart00149
    Location:947 → 1062
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1079 → 1204
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:312 → 491
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:656 → 758
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:538 → 642
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:784 → 843
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:857 → 926
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:27 → 149
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    pfam00169
    Location:100 → 139
    PH; PH domain
    cl17171
    Location:482 → 519
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    42659031..42719211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018234170.2 → XP_018089659.1  phospholipase C gamma 1 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8EU11, A0A974BXU0, A0A974GZH3

  2. XM_018234171.2 → XP_018089660.1  phospholipase C gamma 1 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8EU11, A0A974BXU0, A0A974GZH3
Nucleotide Protein Strain
Heading Accession and Version

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