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arhgef2.S Rho/Rac guanine nucleotide exchange factor 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398353, updated on 17-Aug-2024

Summary

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Official Symbol
arhgef2.S
Official Full Name
Rho/Rac guanine nucleotide exchange factor 2 S homeolog
Primary source
Xenbase:XB-GENE-5909354
Locus tag
XELAEV_18042881mg
See related
EnsemblRapid:ENSXLAG00005029563
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
XLfc; arhgef2
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Genomic context

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Location:
chromosome: 8S
Exon count:
32
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (101318947..101410304, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (96044105..96330440, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene translocon-associated protein subunit beta Neighboring gene relaxin family peptide/INSL5 receptor 4 S homeolog Neighboring gene signal sequence receptor, beta (translocon-associated protein beta) S homeolog Neighboring gene chaperonin containing TCP1 subunit 3 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure. Itoh K, et al. J Cell Sci, 2014 Jun 1. PMID 24681784, Free PMC Article
  2. A novel guanine exchange factor increases the competence of early ectoderm to respond to neural induction. Morgan R, et al. Mech Dev, 1999 Oct. PMID 10525189
  3. XGef influences XRINGO/CDK1 signaling and CPEB activation during Xenopus oocyte maturation. Kuo P, et al. Differentiation, 2011 Feb. PMID 21145160
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. essential for neural tube closure
    Title: GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC82333, MGC86214

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rho/Rac guanine nucleotide exchange factor 2 S homeolog; rho guanine nucleotide exchange factor 2
Names
Rho/Rac guanine nucleotide exchange factor (GEF) 2
guanine nucleotide exchange factor LFC

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    101318947..101410304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574543.1 → XP_041430477.1  rho guanine nucleotide exchange factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8J1LLT4
    Conserved Domains (4) summary
    smart00109
    Location:271 → 317
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:469 → 663
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:817 → 1072
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13393
    Location:702 → 817
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  2. XM_041574542.1 → XP_041430476.1  rho guanine nucleotide exchange factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8J1LMQ4
    Conserved Domains (3) summary
    smart00109
    Location:271 → 317
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:469 → 663
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:702 → 817
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  3. XM_041574544.1 → XP_041430478.1  rho guanine nucleotide exchange factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8J1LMU0, Q6INN2
    Related
    ENSXLAP00005089563.1, ENSXLAT00005091232.1
    Conserved Domains (3) summary
    smart00109
    Location:252 → 298
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:450 → 644
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:683 → 798
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  4. XM_041574545.1 → XP_041430479.1  rho guanine nucleotide exchange factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8J1LMU0, Q6INN2
    Related
    ENSXLAP00005089033.1, ENSXLAT00005090702.1
    Conserved Domains (3) summary
    smart00109
    Location:252 → 298
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:450 → 644
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:683 → 798
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  5. XM_041574546.1 → XP_041430480.1  rho guanine nucleotide exchange factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8J1LMU0, Q6INN2
    Conserved Domains (3) summary
    smart00109
    Location:252 → 298
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:450 → 644
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:683 → 798
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  6. XM_041574549.1 → XP_041430483.1  rho guanine nucleotide exchange factor 2 isoform X6

    UniProtKB/TrEMBL
    A0A8J1LLN3, Q6INN2
    Conserved Domains (3) summary
    smart00109
    Location:28 → 74
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:226 → 420
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:459 → 574
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  7. XM_041574548.1 → XP_041430482.1  rho guanine nucleotide exchange factor 2 isoform X5

    UniProtKB/TrEMBL
    A0A8J1LLT9, Q6INN2
    Related
    ENSXLAP00005088771.1, ENSXLAT00005090440.1
    Conserved Domains (3) summary
    smart00109
    Location:42 → 88
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:240 → 434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:473 → 588
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  8. XM_041574547.1 → XP_041430481.1  rho guanine nucleotide exchange factor 2 isoform X4

    UniProtKB/TrEMBL
    A0A1L8F4X7, A0A974C563, Q6AX47
    Related
    ENSXLAP00005088390.1, ENSXLAT00005090051.1
    Conserved Domains (3) summary
    cd00160
    Location:262 → 456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:495 → 610
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cd20877
    Location:59 → 119
    C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001136164.1: Suppressed sequence

    Description
    NM_001136164.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
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