U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sox3.L SRY-box 3 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398329, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
sox3.L
Official Full Name
SRY-box 3 L homeolog
Primary source
Xenbase:XB-GENE-17345032
Locus tag
XELAEV_18038842mg
See related
EnsemblRapid:ENSXLAG00005011288 AllianceGenome:Xenbase:XB-GENE-17345032
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
Sry; sox11; xSox3; Xlsox3; Xtsox3; sox3-B; xsox-11
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in ectoderm. Human ortholog(s) of this gene implicated in X-linked panhypopituitarism. Orthologous to human SOX3 (SRY-box transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See sox3.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
1
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (46991470..46993062, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (33819043..33820636, complement)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene uncharacterized LOC121397027 Neighboring gene uncharacterized LOC121396831 Neighboring gene uncharacterized LOC108698909

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A conserved family of genes related to the testis determining gene, SRY. Denny P, et al. Nucleic Acids Res, 1992 Jun 11. PMID 1614875, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription factor Sox-3-B
Names
transcription factor Sox-11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173404.1 → NP_001166875.1  transcription factor Sox-3-B

    See identical proteins and their annotated locations for NP_001166875.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089283
    UniProtKB/Swiss-Prot
    Q5FWM3
    UniProtKB/TrEMBL
    A0A974C6D7
    Related
    ENSXLAP00005033151.1, ENSXLAT00005033945.1
    Conserved Domains (3) summary
    cd01388
    Location:39 → 110
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam12336
    Location:109 → 187
    SOXp; SOX transcription factor
    cl21461
    Location:217 → 297
    Globin_like; Globin-like proteins

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    46991470..46993062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWM3.1 GenPept UniProtKB/Swiss-Prot:Q5FWM3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.