spry2.S sprouty RTK signaling antagonist 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: spry2.S
Official Full Name: sprouty RTK signaling antagonist 2 S homeolog
Primary source: Xenbase:XB-GENE-864828
Locus tag: XELAEV_18015695mg
See related: EnsemblRapid:ENSXLAG00005017722 AllianceGenome:Xenbase:XB-GENE-864828
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: spry2; xspry2; sprouty2; Xsprouty2; sprouty-2; Xtsprouty2
Summary: Predicted to act upstream of or within animal organ development and negative regulation of signal transduction. Predicted to be located in cytosol and membrane. Is expressed in several structures, including appendage; ectoderm; mesenchyme; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2S

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (115997368..116007755)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (106927822..106938334)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sprouty2 regulates positioning of retinal progenitors through suppressing the Ras/Raf/MAPK pathway.
Title: Sprouty2 regulates positioning of retinal progenitors through suppressing the Ras/Raf/MAPK pathway.
Results show that Spry1a, 2 and 4 have partially overlapping expression in developing and regenerating Xenopus limbs, which correspond with known areas of Fgf signaling.
Title: Distal expression of sprouty (spry) genes during Xenopus laevis limb development and regeneration.
Here we show that Xenopus laevis Sprouty2 (XSpry2) controls the duration of ERK activity and thereby contributes to the establishment of dorsoventral patterning during mesoderm formation.
Title: Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning.
Data show that the intracellular domain of PAPC interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.
Title: Xenopus Paraxial Protocadherin regulates morphogenesis by antagonizing Sprouty.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sprouty RTK signaling antagonist 2 S homeolog

Names: sprouty 2; sprouty homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.