U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dusp1.S dual specificity phosphatase 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398254, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
dusp1.S
Official Full Name
dual specificity phosphatase 1 S homeolog
Primary source
Xenbase:XB-GENE-17344125
Locus tag
XELAEV_18021426mg
See related
EnsemblRapid:ENSXLAG00005012798 AllianceGenome:Xenbase:XB-GENE-17344125
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
XCL100
Summary
Predicted to enable MAP kinase tyrosine/serine/threonine phosphatase activity; protein serine/threonine phosphatase activity; and protein tyrosine phosphatase activity. Predicted to act upstream of or within negative regulation of meiotic cell cycle; protein dephosphorylation; and regulation of intracellular signal transduction. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dusp1.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
5
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (105080020..105083360)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (103172826..103176146)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene toll-like receptor 22 S homeolog Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1 S homeolog Neighboring gene uncharacterized LOC108713248 Neighboring gene neuralized E3 ubiquitin protein ligase 1B S homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes. Sohaskey ML, et al. Mol Biol Cell, 2002 Feb. PMID 11854404, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC79854

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endoderm formation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-serine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within peptidyl-threonine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dual specificity protein phosphatase 1-B
Names
MAP kinase phosphatase XCL100(beta) protein
dusp1-b
XP_041444645.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    105080020..105083360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041588711.1 → XP_041444645.1  dual specificity protein phosphatase 1-B

    UniProtKB/Swiss-Prot
    Q90W58
    UniProtKB/TrEMBL
    A0A1L8GV49, A0A974D8X9, Q5U4X4
    Related
    ENSXLAP00005037640.1, ENSXLAT00005038551.1
    Conserved Domains (2) summary
    cd01446
    Location:9 → 137
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14638
    Location:176 → 326
    DSP_DUSP1; dual specificity phosphatase domain of dual specificity protein phosphatase 1

RNA

  1. XR_005966693.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001088684.1: Suppressed sequence

    Description
    NM_001088684.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90W58.1 GenPept UniProtKB/Swiss-Prot:Q90W58

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials