fbxo5.S F-box protein 5 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: fbxo5.S
Official Full Name: F-box protein 5 S homeolog
Primary source: Xenbase:XB-GENE-953951
Locus tag: XELAEV_18028993mg
See related: EnsemblRapid:ENSXLAG00005005854 AllianceGenome:Xenbase:XB-GENE-953951
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: emi1; fbx5; fbxo5; emi1-a; fbxo5-a; fbxo5-b
Summary: Predicted to enable ubiquitin ligase inhibitor activity. Acts upstream of or within negative regulation of exit from meiosis; negative regulation of mitotic metaphase/anaphase transition; and negative regulation of ubiquitin protein ligase activity. Located in cytoplasm; nucleus; and spindle. Orthologous to human FBXO5 (F-box protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 5S

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (39758656..39765455)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (39607564..39614371)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Emi1 has a role in regulating entry into meiosis and the meiosis I to meiosis II transition in Xenopus oocytes
Title: Emi1 class of proteins regulate entry into meiosis and the meiosis I to meiosis II transition in Xenopus oocytes.
Data show that the anaphase-promoting complex (APC/C)-Cdc20 can mediate cyclin B degradation in cytostatic factor-arrested Xenopus eggs and extracts.
Title: APC/C-Cdc20-mediated degradation of cyclin B participates in CSF arrest in unfertilized Xenopus eggs.
Results indicate that Emi1 is unlikely to be a component of cytostatic factor.
Title: Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin ligase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell cycle process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of exit from meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mitotic metaphase/anaphase transition	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F-box only protein 5-A

Names: early mitotic inhibitor 1-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.