snai2.S snail family transcriptional repressor 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: snai2.S
Official Full Name: snail family transcriptional repressor 2 S homeolog
Primary source: Xenbase:XB-GENE-865699
Locus tag: XELAEV_18033703mg
See related: EnsemblRapid:ENSXLAG00005029708 AllianceGenome:Xenbase:XB-GENE-865699
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: slug; xSlu; snai2; xslug; Snail2; XSnail2; snai2-a; snai2-b
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and metal ion binding activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in ectoderm and vestibuloauditory system. Human ortholog(s) of this gene implicated in piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6S

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (99170749..99174462, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6S	NC_030735.1 (90488174..90491887, complement)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Slug controls epithelial-mesenchymal transitions during both embryonic development and tumor metastasis.
Title: The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1.
A dinucleotide TGTGT/ACACA repeat in the cis-element of Snail2 (previously 'Slug') gene contributes to repression of neural crest cell differentiation and migration by all-trans retinoic acid in Xenopus laevis embryos.
Title: Polypyrimidine tract-binding protein is required for the repression of gene expression by all-trans retinoic acid.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: snail family transcriptional repressor 2 S homeolog

Names: snail family zinc finger 2 S homeolog; snail homolog 2; zinc finger transcription factor slug beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088649.1 → NP_001082118.1 snail family transcriptional repressor 2 S homeolog

See identical proteins and their annotated locations for NP_001082118.1

Status: PROVISIONAL

Source sequence(s)

AF368043

UniProtKB/TrEMBL

A0A974HEN6, Q6IP32, Q90VW5

Related

ENSXLAP00005088838.1, ENSXLAT00005090507.1

Conserved Domains (5) summary

sd00017
Location:185 → 205

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:128 → 148

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:211 → 233

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:198 → 221

zf-H2C2_2; Zinc-finger double domain

pfam15961
Location:82 → 160

DUF4764; Domain of unknown function (DUF4764)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

99170749..99174462 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)