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agxt.L alanine--glyoxylate and serine-- pyruvate aminotransferase L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398137, updated on 4-Nov-2024

Summary

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Official Symbol
agxt.L
Official Full Name
alanine--glyoxylate and serine-- pyruvate aminotransferase L homeolog
Primary source
Xenbase:XB-GENE-950845
Locus tag
XELAEV_18027830mg
See related
EnsemblRapid:ENSXLAG00005015756 AllianceGenome:Xenbase:XB-GENE-950845
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
agt; spt; agt1; agxt; agxt1
Summary
Predicted to enable L-serine-pyruvate transaminase activity and alanine-glyoxylate transaminase activity. Predicted to act upstream of or within glycine biosynthetic process, by transamination of glyoxylate. Predicted to be located in peroxisome. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See agxt.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (135497288..135518524, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (124417524..124438760, complement)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene sushi, nidogen and EGF-like domains 1 L homeolog Neighboring gene rootletin Neighboring gene allantoinase, mitochondrial-like L homeolog Neighboring gene kinesin family member 1A L homeolog Neighboring gene tRNA methyltransferase 10A L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular basis for the dual mitochondrial and cytosolic localization of alanine:glyoxylate aminotransferase in amphibian liver cells. Holbrook JD, et al. J Biol Chem, 2002 Jan 18. PMID 11694530
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables L-serine-pyruvate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables alanine-glyoxylate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glycine biosynthetic process, by transamination of glyoxylate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alanine-glyoxylate aminotransferase
Names
alanine-glyoxylate aminotransferase L homeolog
putative alanine:glyoxylate aminotransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088479.2 → NP_001081948.1  alanine-glyoxylate aminotransferase

    See identical proteins and their annotated locations for NP_001081948.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ278065
    UniProtKB/TrEMBL
    A0A974HJZ8, Q6DED5, Q9DEN7
    Related
    ENSXLAP00005046313.1, ENSXLAT00005047418.1
    Conserved Domains (2) summary
    cd06451
    Location:47 → 408
    AGAT_like; Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), ...
    COG0075
    Location:46 → 407
    PucG; Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG [Amino acid transport and metabolism, Nucleotide transport and metabolism]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    135497288..135518524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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