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nradd.L neurotrophin receptor associated death domain L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398134, updated on 4-Nov-2024

Summary

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Official Symbol
nradd.L
Official Full Name
neurotrophin receptor associated death domain L homeolog
Primary source
Xenbase:XB-GENE-17344686
Locus tag
XELAEV_18030542mg
See related
EnsemblRapid:ENSXLAG00005026149 AllianceGenome:Xenbase:XB-GENE-17344686
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
nrdd; plaidd
Summary
Predicted to enable coreceptor activity; death receptor activity; and nerve growth factor binding activity. Predicted to act upstream of or within Rho protein signal transduction and apoptotic process. Predicted to be located in cell surface and plasma membrane. Is expressed in nervous system. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See nradd.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (6306629..6325994)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (3865663..3885054)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene cAMP-dependent protein kinase type 3-like Neighboring gene uncharacterized LOC121394847 Neighboring gene serine/threonine-protein kinase N1-like Neighboring gene SET domain containing 2 L homeolog Neighboring gene zeta tubulin L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterisation of the posteriorly-expressed Xenopus neurotrophin receptor homolog genes fullback and fullback-like. Bromley E, et al. Gene Expr Patterns, 2004 Nov. PMID 15533829
  2. The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements. Sasai N, et al. Nat Cell Biol, 2004 Aug. PMID 15258592
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. fullback and fullback-like have different functions from p75NTR during early development.
    Title: Identification and characterisation of the posteriorly-expressed Xenopus neurotrophin receptor homolog genes fullback and fullback-like.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
  
enables death receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nerve growth factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neurotrophin receptor associated death domain L homeolog
Names
p75-like apoptosis-inducing death domain protein
p75-like transmembrane protein fullback

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088475.1 → NP_001081944.1  neurotrophin receptor associated death domain L homeolog precursor

    See identical proteins and their annotated locations for NP_001081944.1

    Status: PROVISIONAL

    Source sequence(s)
    AF131890
    UniProtKB/TrEMBL
    Q4KLX7, Q9PVD4
    Related
    ENSXLAP00005077742.1, ENSXLAT00005079333.1
    Conserved Domains (2) summary
    cd08311
    Location:299 → 378
    Death_p75NR; Death domain of p75 Neurotrophin Receptor
    cd13416
    Location:23 → 182
    TNFRSF16; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    6306629..6325994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials