cdc45.L cell division cycle 45 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: cdc45.L
Official Full Name: cell division cycle 45 L homeolog
Primary source: Xenbase:XB-GENE-976062
Locus tag: XELAEV_18007695mg
See related: EnsemblRapid:ENSXLAG00005013187 AllianceGenome:Xenbase:XB-GENE-976062
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cdc45; cdc45l; cdc45l2; xCdc45p; porc-pi-1
Summary: Enables chromatin binding activity. Predicted to act upstream of or within DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Part of CMG complex. Is expressed in ectoderm; nervous system; pharyngeal arch; vestibuloauditory system; and visual system. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (167501356..167519264)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (154288926..154306845)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.
Title: RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA replication origin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via break-induced replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic DNA replication preinitiation complex assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CMG complex	IDA Inferred from Direct Assay more info	PubMed
part_of DNA replication preinitiation complex	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell division control protein 45 homolog

Names: CDC45 cell division cycle 45 homolog; CDC45-related protein; cell division cycle 45 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.