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mcm6.2.L minichromosome maintenance complex component 6 gene 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398071, updated on 4-Nov-2024

Summary

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Official Symbol
mcm6.2.L
Official Full Name
minichromosome maintenance complex component 6 gene 2 L homeolog
Primary source
Xenbase:XB-GENE-5870555
Locus tag
XELAEV_18031210mg
See related
EnsemblRapid:ENSXLAG00005026386 AllianceGenome:Xenbase:XB-GENE-5870555
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
mcm6; mis5; mmcm6; mcm6.L
Summary
Contributes to ATP hydrolysis activity and chromatin binding activity. Acts upstream of or within DNA unwinding involved in DNA replication and regulation of DNA-templated DNA replication initiation. Located in chromatin. Part of CMG complex and MCM complex. Orthologous to human MCM6 (minichromosome maintenance complex component 6). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See mcm6.2.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
17
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (62814279..62868565, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (57481418..57536158, complement)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene insulin like growth factor binding protein 1 L homeolog Neighboring gene adenylate cyclase 1 (brain) L homeolog Neighboring gene uncharacterized LOC121394635 Neighboring gene receptor (G protein-coupled) activity modifying protein 3 L homeolog Neighboring gene chromosome 6 C7orf57 homolog L homeolog Neighboring gene HUS1 checkpoint clamp component L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for different MCM subcomplexes with differential binding to chromatin in Xenopus. Coué M, et al. Exp Cell Res, 1998 Dec 15. PMID 9851868
  2. Developmental regulation of MCM replication factors in Xenopus laevis. Sible JC, et al. Curr Biol, 1998 Mar 12. PMID 9512418
  3. The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides. Thömmes P, et al. EMBO J, 1997 Jun 2. PMID 9214646, Free PMC Article
  4. The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding. Ying CY, et al. EMBO J, 2005 Dec 21. PMID 16369567, Free PMC Article
  5. Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs. Kubota Y, et al. EMBO J, 1997 Jun 2. PMID 9214647, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC85070

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA unwinding involved in DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within DNA unwinding involved in DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair via break-induced replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CMG complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MCM complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
maternal DNA replication licensing factor mcm6
Names
maternal Mcm6 protein
maternal minichromosome maintenance protein 6
minichromosome maintenance complex component 6 L homeolog
mis5p
xMCM6
NP_001081822.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088353.1 → NP_001081822.1  maternal DNA replication licensing factor mcm6

    See identical proteins and their annotated locations for NP_001081822.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089118
    UniProtKB/Swiss-Prot
    O42590, Q5FWY4
    UniProtKB/TrEMBL
    A0A090AZM4, A0A974HFI3
    Related
    ENSXLAP00005078726.1, ENSXLAT00005080318.1
    Conserved Domains (3) summary
    smart00350
    Location:124 → 659
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:31 → 141
    MCM_N; MCM N-terminal domain
    cl21455
    Location:449 → 536
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    62814279..62868565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWY4.1 GenPept UniProtKB/Swiss-Prot:Q5FWY4

Gene LinkOut

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