szl.S sizzled S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: szl.S
Official Full Name: sizzled S homeolog
Primary source: Xenbase:XB-GENE-17342129
Locus tag: XELAEV_18021029mg
See related: EnsemblRapid:ENSXLAG00005007246 AllianceGenome:Xenbase:XB-GENE-17342129
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: szl; xszl; frzb3; sizzled
Summary: Predicted to enable G protein-coupled receptor activity and Wnt-protein binding activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; canonical Wnt signaling pathway; and non-canonical Wnt signaling pathway. Predicted to be located in extracellular space and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3S

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (77119335..77123030, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3S	NC_030729.1 (75687457..75691054, complement)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Sizzled is unlikely able to antagonize Wnt signaling; however, structure of Sizzled provides a framework for understanding full-length structure of secreted Frizzled-related proteins such as frizzled-8 and their interaction with and antagonism of Wnt proteins such as Wnt-8.
Title: The crystal structure of full-length Sizzled from Xenopus laevis yields insights into Wnt-antagonistic function of secreted Frizzled-related proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sizzled S homeolog

Names: secreted Xwnt8 inhibitor sizzled; secreted frizzled

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088279.1 → NP_001081748.1 sizzled S homeolog precursor

See identical proteins and their annotated locations for NP_001081748.1

Status: PROVISIONAL

Source sequence(s)

AF059570

UniProtKB/TrEMBL

O73821

Related

ENSXLAP00005020811.1, ENSXLAT00005021392.1

Conserved Domains (2) summary

cd07452
Location:19 → 159

CRD_sizzled; Cysteine-rich domain of the sizzled protein

cd03580
Location:153 → 281

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

77119335..77123030 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041587514.1 → XP_041443448.1 sizzled S homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1MPX0

Conserved Domains (2) summary

cd07452
Location:19 → 159

CRD_sizzled; Cysteine-rich domain of the sizzled protein

cd03580
Location:153 → 281

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...