kpna7.L karyopherin alpha 7 (importin alpha 8) L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: kpna7.L
Official Full Name: karyopherin alpha 7 (importin alpha 8) L homeolog
Primary source: Xenbase:XB-GENE-17334456
Locus tag: XELAEV_18045061mg
See related: EnsemblRapid:ENSXLAG00005025479 AllianceGenome:Xenbase:XB-GENE-17334456
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: kpna2
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to act upstream of or within NLS-bearing protein import into nucleus. Predicted to be located in cytoplasm and nucleus. Orthologous to human KPNA7 (karyopherin subunit alpha 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (95522545..95548370, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (84943966..84969763, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear import rates correlated with nuclear size, and varying the concentrations of two transport factors, importin alpha and Ntf2, was sufficient to account for nuclear scaling between the two species.
Title: Nuclear size is regulated by importin α and Ntf2 in Xenopus.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear localization sequence binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NLS-bearing protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: importin subunit alpha-1

Names: importin alpha 1b; importin subunit alpha-2; karyopherin subunit alpha-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088275.1 → NP_001081744.1 importin subunit alpha-1

See identical proteins and their annotated locations for NP_001081744.1

Status: PROVISIONAL

Source sequence(s)

BC124992

UniProtKB/Swiss-Prot

P52171

UniProtKB/TrEMBL

Q0VGW7

Related

ENSXLAP00005075762.1, ENSXLAT00005077342.1

Conserved Domains (5) summary

COG5064
Location:8 → 523

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

cd00020
Location:111 → 231

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam01749
Location:7 → 95

IBB; Importin beta binding domain

pfam16186
Location:451 → 501

Arm_3; Atypical Arm repeat

sd00043
Location:111 → 144

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

95522545..95548370 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018234147.2 → XP_018089636.1 importin subunit alpha-1 isoform X1

UniProtKB/Swiss-Prot

P52171

UniProtKB/TrEMBL

A0A1L8EXD5, A0A974H4D1

Conserved Domains (2) summary

COG5064
Location:8 → 523

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:111 → 144

ARM; armadillo repeat [structural motif]
XM_041575532.1 → XP_041431466.1 importin subunit alpha-1 isoform X1

UniProtKB/Swiss-Prot

P52171

UniProtKB/TrEMBL

A0A1L8EXD5, A0A974H4D1

Conserved Domains (2) summary

COG5064
Location:8 → 523

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:111 → 144

ARM; armadillo repeat [structural motif]