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kpna7.S karyopherin alpha 7 (importin alpha 8) S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398026, updated on 4-Nov-2024

Summary

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Official Symbol
kpna7.S
Official Full Name
karyopherin alpha 7 (importin alpha 8) S homeolog
Primary source
Xenbase:XB-GENE-5991815
Locus tag
XELAEV_18047436mg
See related
EnsemblRapid:ENSXLAG00005016342 AllianceGenome:Xenbase:XB-GENE-5991815
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
kpna1; kpna7
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to act upstream of or within NLS-bearing protein import into nucleus. Predicted to be located in cytoplasm and nucleus. Orthologous to human KPNA7 (karyopherin subunit alpha 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kpna7.S in Genome Data Viewer
Location:
chromosome: 9_10S
Exon count:
12
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (83138062..83156256, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (76443329..76461800, complement)

Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene fascin actin-bundling protein 1 S homeolog Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 S homeolog Neighboring gene potassium inwardly rectifying channel subfamily J member 12 S homeolog Neighboring gene ATP synthase membrane subunit f S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro. Hachet V, et al. EMBO J, 2004 Apr 7. PMID 15014441, Free PMC Article
  2. Isolation of a protein that is essential for the first step of nuclear protein import. Görlich D, et al. Cell, 1994 Dec 2. PMID 8001116
  3. A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus. Görlich D, et al. EMBO J, 1996 Apr 15. PMID 8617226, Free PMC Article
  4. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Görlich D, et al. Curr Biol, 1995 Apr 1. PMID 7627554
  5. The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA. Kim DH, et al. Mol Cell Biol, 2010 Sep. PMID 20606006, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear localization sequence binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within NLS-bearing protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
importin subunit alpha-5
Names
importin alpha 1a
importin subunit alpha-1
karyopherin subunit alpha-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088273.1 → NP_001081742.1  importin subunit alpha-5

    See identical proteins and their annotated locations for NP_001081742.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097584
    UniProtKB/Swiss-Prot
    P52171
    UniProtKB/TrEMBL
    Q4QR45
    Related
    ENSXLAP00005048152.1, ENSXLAT00005049267.1
    Conserved Domains (5) summary
    COG5064
    Location:8 → 522
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:111 → 231
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:7 → 95
    IBB; Importin beta binding domain
    pfam16186
    Location:451 → 501
    Arm_3; Atypical Arm repeat
    sd00043
    Location:111 → 144
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    83138062..83156256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018237324.2 → XP_018092813.1  importin subunit alpha-5 isoform X1

    UniProtKB/Swiss-Prot
    P52170, P52171
    UniProtKB/TrEMBL
    A0A1L8EPY1, A0A974H1J9
    Conserved Domains (2) summary
    COG5064
    Location:8 → 522
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:111 → 144
    ARM; armadillo repeat [structural motif]

  2. XM_041577687.1 → XP_041433621.1  importin subunit alpha-5 isoform X1

    UniProtKB/Swiss-Prot
    P52170, P52171
    UniProtKB/TrEMBL
    A0A1L8EPY1, A0A974H1J9
    Conserved Domains (2) summary
    COG5064
    Location:8 → 522
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:111 → 144
    ARM; armadillo repeat [structural motif]

  3. XM_018237323.2 → XP_018092812.1  importin subunit alpha-5 isoform X1

    UniProtKB/Swiss-Prot
    P52170, P52171
    UniProtKB/TrEMBL
    A0A1L8EPY1, A0A974H1J9
    Conserved Domains (2) summary
    COG5064
    Location:8 → 522
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:111 → 144
    ARM; armadillo repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52170.2 GenPept UniProtKB/Swiss-Prot:P52170

Gene LinkOut

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