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not.S notochord homeobox S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397961, updated on 4-Nov-2024

Summary

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Official Symbol
not.S
Official Full Name
notochord homeobox S homeolog
Primary source
Xenbase:XB-GENE-865187
Locus tag
XELAEV_18008736mg
See related
EnsemblRapid:ENSXLAG00005000582 AllianceGenome:Xenbase:XB-GENE-865187
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
flh; not; Znot; not1; nota; noto; Xnot1; Xnot2; not-a; not-b; not.L; Xnot-2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription and notochord formation. Predicted to be located in nucleus. Is expressed in ectoderm; mesoderm; nervous system; pharyngeal arch; and visual system. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See not.S in Genome Data Viewer
Location:
chromosome: 1S
Exon count:
4
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (2837785..2840015)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (2708506..2709816)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene sideroflexin-5-like Neighboring gene sideroflexin-5 Neighboring gene uncharacterized LOC108704059 Neighboring gene uncharacterized LOC100174801 Neighboring gene ALMS1, centrosome and basal body associated protein S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. von Dassow G, et al. Genes Dev, 1993 Mar. PMID 8095482
  2. Role of Goosecoid, Xnot and Wnt antagonists in the maintenance of the notochord genetic programme in Xenopus gastrulae. Yasuo H, et al. Development, 2001 Oct. PMID 11585804
  3. derrière: a TGF-beta family member required for posterior development in Xenopus. Sun BI, et al. Development, 1999 Apr. PMID 10068640
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within central nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within notochord formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homeobox protein notochord
Names
Xnot protein
floating head
notochord homeobox L homeolog
notochord homeobox a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088156.1 → NP_001081625.1  homeobox protein notochord

    See identical proteins and their annotated locations for NP_001081625.1

    Status: PROVISIONAL

    Source sequence(s)
    Z19577
    UniProtKB/Swiss-Prot
    Q06615, Q0IHA7
    UniProtKB/TrEMBL
    B7ZPL0
    Related
    ENSXLAP00005001587.1, ENSXLAT00005001627.1
    Conserved Domains (1) summary
    pfam00046
    Location:142 → 194
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    2837785..2840015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041573627.1 → XP_041429561.1  homeobox protein notochord isoform X1

    UniProtKB/TrEMBL
    A0A1L8HKC2, A0A974DRE9
    Conserved Domains (1) summary
    pfam00046
    Location:142 → 195
    Homeobox; Homeobox domain

  2. XM_041573617.1 → XP_041429551.1  homeobox protein notochord isoform X1

    UniProtKB/TrEMBL
    A0A1L8HKC2, A0A974DRE9
    Conserved Domains (1) summary
    pfam00046
    Location:142 → 195
    Homeobox; Homeobox domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06615.1 GenPept UniProtKB/Swiss-Prot:Q06615

Gene LinkOut

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