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ddx3x.S DEAD-box helicase 3 X-linked S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397935, updated on 4-Nov-2024

Summary

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Official Symbol
ddx3x.S
Official Full Name
DEAD-box helicase 3 X-linked S homeolog
Primary source
Xenbase:XB-GENE-17330554
Locus tag
XELAEV_18014742mg
See related
EnsemblRapid:ENSXLAG00005028924 AllianceGenome:Xenbase:XB-GENE-17330554
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
an3
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cell leading edge and cytoplasm. Predicted to be part of canonical inflammasome complex. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ddx3x.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
19
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (48892977..48909224, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (46067329..46081024, complement)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent serine protein kinase (MAGUK family) S homeolog Neighboring gene probable G-protein coupled receptor 82 Neighboring gene nyctalopin S homeolog Neighboring gene ribosomal protein L8 S homeolog Neighboring gene ubiquitin specific peptidase 9 X-linked S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase. Gururajan R, et al. Nature, 1991 Feb 21. PMID 1996140
  2. Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. Yedavalli VS, et al. Cell, 2004 Oct 29. PMID 15507209
  3. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, et al. Nat Commun, 2020 Mar 6. PMID 32144273, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gamete generation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in P granule IEA
Inferred from Electronic Annotation
more info
  
part_of canonical inflammasome complex IEA
Inferred from Electronic Annotation
more info
  
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative ATP-dependent RNA helicase an3
Names
ATP dependent RNA helicase
NP_001095245.1
XP_041438944.1
XP_041438945.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101775.1 → NP_001095245.1  putative ATP-dependent RNA helicase an3

    See identical proteins and their annotated locations for NP_001095245.1

    Status: PROVISIONAL

    Source sequence(s)
    X57328
    UniProtKB/Swiss-Prot
    P24346
    UniProtKB/TrEMBL
    A0A974HV98, Q52L23
    Conserved Domains (3) summary
    cd00268
    Location:223 → 445
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:79 → 618
    PTZ00110; helicase; Provisional
    pfam00271
    Location:467 → 577
    Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    48892977..48909224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041583010.1 → XP_041438944.1  putative ATP-dependent RNA helicase an3 isoform X1

    UniProtKB/TrEMBL
    A0A8J1MB61, A0A974HV98, Q52L23
    Related
    ENSXLAP00005087348.1, ENSXLAT00005089009.1
    Conserved Domains (2) summary
    PTZ00110
    Location:89 → 640
    PTZ00110; helicase; Provisional
    cd18051
    Location:223 → 473
    DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3

  2. XM_041583011.1 → XP_041438945.1  putative ATP-dependent RNA helicase an3 isoform X2

    UniProtKB/TrEMBL
    A0A8J1MCX7
    Related
    ENSXLAP00005087136.1, ENSXLAT00005088798.1
    Conserved Domains (2) summary
    cd18787
    Location:309 → 439
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cd18051
    Location:54 → 304
    DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24346.1 GenPept UniProtKB/Swiss-Prot:P24346

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