aurka.L aurora kinase A L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: aurka.L
Official Full Name: aurora kinase A L homeolog
Primary source: Xenbase:XB-GENE-866460
Locus tag: XELAEV_18043488mg
See related: EnsemblRapid:ENSXLAG00005032349 AllianceGenome:Xenbase:XB-GENE-866460
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: Eg2; aik; ark1; aura; btak; stk6; stk7; ARK-1; aur-a; aurka; stk15; aurka-a; aurora2
Summary: Enables kinesin binding activity; microtubule binding activity; and protein serine/threonine kinase activity. Acts upstream of or within mitotic spindle assembly; peptidyl-serine phosphorylation; and protein autophosphorylation. Located in cytoplasm and microtubule cytoskeleton. Is expressed in anatomical system; ectoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (13470302..13482285, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (13379657..13391621, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest a novel relationship between AurA and protein phosphatases during progression throughout the early embryonic cell cycle and shed new light on potential defects caused by AurA overexpression.
Title: Evidence toward a dual phosphatase mechanism that restricts Aurora A (Thr-295) phosphorylation during the early embryonic cell cycle.
MCAK colocalized with NuMA and XMAP215 at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing
Title: Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.
Plx1 promotes activation of Aurora A, most likely through TPX2.
Title: Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A.
Data show that Aurora A is a key regulator of microtubule assembly during M phase and therefore of bipolar spindle formation.
Title: Dissecting the role of Aurora A during spindle assembly.
Aurora-A kinase is required for astral microtubule polymerization and spindle microtubule flux during chromosome segregation.
Title: Requirement of aurora-A kinase in astral microtubule polymerization and spindle microtubule flux.
Results suggest that phosphorylation of maskin by Aurora-A prevents meiosis II proteins from being produced during meiosis I.
Title: Phosphorylation of maskin by Aurora-A participates in the control of sequential protein synthesis during Xenopus laevis oocyte maturation.
binding and elution properties of both the phosphopeptides and unphosphorylated peptides of His6-Aurora A
Title: Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography.
The N-terminal non-catalytic domain of Aurora-A can localize to the centrosome in Xenopus egg extracts, while GFP fusions of either the N-terminal or catalytic domains are targeted to the centrosome in Xenopus XL2 cells.
Title: Aurora A, meiosis and mitosis.
Here we identify G205 in Xenopus Aurora A as a key determinant of both intrinsic activity and regulation by TPX2
Title: The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2.
The catalytic domain alone of Aurora-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing.
Title: Aurora A, mitotic entry, and spindle bipolarity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within centrosome cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic centrosome separation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cytokinesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in spindle microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	IEA Inferred from Electronic Annotation more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole centrosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aurora kinase A-A

Names: Aurora A; aurora-A; aurora-related kinase 1; aurora/IPL1-related kinase 1; p46Eg265; pEg2; serine/threonine-protein kinase 6; serine/threonine-protein kinase 6-A; serine/threonine-protein kinase Eg2; serine/threonine-protein kinase Eg2-A; serine/threonine-protein kinase aurora-A

NP_001081565.1

EC 2.7.11.1

XP_018089632.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088096.1 → NP_001081565.1 aurora kinase A-A

See identical proteins and their annotated locations for NP_001081565.1

Status: PROVISIONAL

Source sequence(s)

Z17207

UniProtKB/Swiss-Prot

Q6INY9, Q91820

UniProtKB/TrEMBL

A0A974BSV8, A0A974BX18

Related

ENSXLAP00005097019.1, ENSXLAT00005098801.1

Conserved Domains (2) summary

smart00220
Location:140 → 390

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14116
Location:134 → 391

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

13470302..13482285 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)