lmnb3.L lamin B3 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: lmnb3.L
Official Full Name: lamin B3 L homeolog
Primary source: Xenbase:XB-GENE-920628
Locus tag: XELAEV_18018277mg
See related: EnsemblRapid:ENSXLAG00005001768
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: LB3; lmnb3; lmnb3-a; lmnb3.S
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Genomic context

Location:: chromosome: 3L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (111271892..111291848, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (95825582..95845539, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Xenopus lamin LIV and mammalian B3 assemble into short structures rather than into long IF-like filaments.
Title: Molecular characterization of Xenopus lamin LIV reveals differences in the lamin composition of sperms in amphibians and mammals.
These results indicate that thyroid hormone-regulated expression of nuclear lamin A and LIII closely correlates with dedifferentiation of the epithelial cells in the X. laevis intestine.
Title: Thyroid hormone-regulated expression of nuclear lamins correlates with dedifferentiation of intestinal epithelial cells during Xenopus laevis metamorphosis.
Nudel regulates microtubule organization in part by facilitating assembly of the lamin B spindle matrix in a dynein-dependent manner.
Title: Requirement for Nudel and dynein for assembly of the lamin B spindle matrix.
LIII filaments appear identical to the endogenous lamina, whereas lamin B2 assembles into filaments that are organized less precisely; Lamin A induces sheets of thicker filaments on the endogenous lamina and increases the rigidity of the nuclear envelope
Title: Filaments made from A- and B-type lamins differ in structure and organization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heterochromatin formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear envelope organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear pore localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to nuclear envelope	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear lamina	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lamin-B3; lamin-L(III)

Names: lamin B3 S homeolog; lamin LIII; lamin LIV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088076.1 → NP_001081545.1 lamin-B3

See identical proteins and their annotated locations for NP_001081545.1

Status: PROVISIONAL

Source sequence(s)

X13169

UniProtKB/Swiss-Prot

P10999, P23420, Q6AZG7

UniProtKB/TrEMBL

A0A974HTI4

Related

ENSXLAP00005005263.1, ENSXLAT00005005369.1

Conserved Domains (3) summary

pfam00038
Location:29 → 385

Filament; Intermediate filament protein

pfam00932
Location:434 → 543

LTD; Lamin Tail Domain

pfam07106
Location:103 → 195

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

111271892..111291848 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)