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nr3c1.L nuclear receptor subfamily 3 group C member 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397897, updated on 4-Nov-2024

Summary

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Official Symbol
nr3c1.L
Official Full Name
nuclear receptor subfamily 3 group C member 1 L homeolog
Primary source
Xenbase:XB-GENE-865499
Locus tag
XELAEV_18017199mg
See related
EnsemblRapid:ENSXLAG00005033930 AllianceGenome:Xenbase:XB-GENE-865499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
GR; gcr; grl; xGR; gccr; nr3c1; nr3c1-a; nr3c1-b; nr3c1.S
Summary
Predicted to enable several functions, including estrogen response element binding activity; nuclear glucocorticoid receptor activity; and zinc ion binding activity. Predicted to act upstream of or within chromatin organization; regulation of transcription by RNA polymerase II; and steroid hormone receptor signaling pathway. Predicted to be located in microtubule cytoskeleton; mitochondrion; and nucleus. Is expressed in ectoderm; mesenchyme; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nr3c1.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
12
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (46037048..46174179, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (31662038..31798252, complement)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121401166 Neighboring gene Rho GTPase activating protein 26 L homeolog Neighboring gene DC-STAMP domain-containing protein 2-like Neighboring gene DC-STAMP domain-containing protein 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the glucocorticoid receptor gene is regulated during early embryogenesis of Xenopus laevis. Gao X, et al. Biochim Biophys Acta, 1994 Jun 21. PMID 8018720
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables estrogen response element binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear glucocorticoid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucocorticoid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nuclear receptor-mediated glucocorticoid signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nuclear receptor-mediated steroid hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucocorticoid receptor
Names
glucocorticoid receptor protein
nuclear receptor subfamily 3 group C member 1 S homeolog
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088062.2 → NP_001081531.1  glucocorticoid receptor

    See identical proteins and their annotated locations for NP_001081531.1

    Status: VALIDATED

    Source sequence(s)
    BC077547, JAGEVR010000048
    UniProtKB/Swiss-Prot
    P49844
    UniProtKB/TrEMBL
    A0A974DC11, Q6DDL0
    Related
    ENSXLAP00005101295.1, ENSXLAT00005103270.1
    Conserved Domains (3) summary
    cd07076
    Location:530 → 776
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:418 → 493
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:29 → 401
    GCR; Glucocorticoid receptor

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    46037048..46174179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018250792.2 → XP_018106281.1  glucocorticoid receptor isoform X1

    UniProtKB/Swiss-Prot
    P49844
    UniProtKB/TrEMBL
    A0A974DC11, Q6DDL0
    Conserved Domains (3) summary
    cd07076
    Location:530 → 776
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:418 → 493
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:29 → 401
    GCR; Glucocorticoid receptor

  2. XM_018250791.2 → XP_018106280.1  glucocorticoid receptor isoform X1

    UniProtKB/Swiss-Prot
    P49844
    UniProtKB/TrEMBL
    A0A974DC11, Q6DDL0
    Conserved Domains (3) summary
    cd07076
    Location:530 → 776
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:418 → 493
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:29 → 401
    GCR; Glucocorticoid receptor

  3. XM_041584998.1 → XP_041440932.1  glucocorticoid receptor isoform X1

    UniProtKB/Swiss-Prot
    P49844
    UniProtKB/TrEMBL
    A0A974DC11, Q6DDL0
    Conserved Domains (3) summary
    cd07076
    Location:530 → 776
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:418 → 493
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:29 → 401
    GCR; Glucocorticoid receptor
Nucleotide Protein Strain
Heading Accession and Version

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