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hbg2.L hemoglobin subunit gamma 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397871, updated on 4-Nov-2024

Summary

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Official Symbol
hbg2.L
Official Full Name
hemoglobin subunit gamma 2 L homeolog
Primary source
Xenbase:XB-GENE-5808117
Locus tag
XELAEV_18045085mg
See related
EnsemblRapid:ENSXLAG00005028024 AllianceGenome:Xenbase:XB-GENE-5808117
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hbb2; hbg2; hbg2-a; hbg2-b; hbg2.S; beta-T2
Summary
Predicted to enable several functions, including haptoglobin binding activity; heme binding activity; and oxygen binding activity. Predicted to act upstream of or within hydrogen peroxide catabolic process and oxygen transport. Predicted to be located in blood microparticle. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in liver and biliary system. Human ortholog(s) of this gene implicated in delta beta-thalassemia and sickle cell anemia. Orthologous to human HBG2 (hemoglobin subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hbg2.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (96071872..96073691, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (85494432..85496251, complement)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene uncharacterized XB5745823 L homeolog Neighboring gene hemoglobin subunit beta-2-like Neighboring gene RNA-binding protein 44 Neighboring gene potassium channel tetramerization domain containing 18 L homeolog Neighboring gene rhomboid 5 homolog 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence analysis of the larval beta II-globin gene of Xenopus laevis. Meyerhof W, et al. Mol Biol Rep, 1986. PMID 3020391
  2. Comparative nucleotide sequence analysis of two types of larval beta-globin mRNAs of Xenopus laevis. Knöchel W, et al. Nucleic Acids Res, 1985 Nov 11. PMID 2999708, Free PMC Article
  3. Developmental changes in the pattern of larval beta-globin gene expression in Xenopus laevis. Identification of two early larval beta-globin mRNA sequences. Banville D, et al. J Mol Biol, 1985 Aug 20. PMID 2413218
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables haptoglobin binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables organic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oxygen transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
  
part_of haptoglobin-hemoglobin complex IEA
Inferred from Electronic Annotation
more info
  
part_of hemoglobin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hemoglobin subunit beta-2
Names
B2G
adult b2 globin
beta-2-globin
hemoglobin beta-2 chain
hemoglobin beta-minor chain
hemoglobin subunit gamma 2 S homeolog
hemoglobin, gamma G
larval beta II globin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088028.2 → NP_001081497.1  hemoglobin subunit beta-2

    See identical proteins and their annotated locations for NP_001081497.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078566
    UniProtKB/Swiss-Prot
    P02133, P06644, Q66KT5
    UniProtKB/TrEMBL
    A0A974C0C1
    Related
    ENSXLAP00005083309.1, ENSXLAT00005084947.1
    Conserved Domains (1) summary
    cd08925
    Location:7 → 146
    Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    96071872..96073691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02133.2 GenPept UniProtKB/Swiss-Prot:P02133

Gene LinkOut

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