U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mcm7.S minichromosome maintenance complex component 7 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397852, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
mcm7.S
Official Full Name
minichromosome maintenance complex component 7 S homeolog
Primary source
Xenbase:XB-GENE-5946952
Locus tag
XELAEV_18000877mg
See related
EnsemblRapid:ENSXLAG00005009800 AllianceGenome:Xenbase:XB-GENE-5946952
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
mcm7; cdc47; mcm7-a; mcm7-b
Summary
Contributes to ATP hydrolysis activity and chromatin binding activity. Acts upstream of or within DNA unwinding involved in DNA replication; premeiotic DNA replication; and regulation of DNA-templated DNA replication initiation. Located in chromatin. Part of CMG complex and MCM complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mcm7.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
16
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (127448772..127473725)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694811.1 (3942337..3967204)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene galactose-3-O-sulfotransferase 4, gene 5 S homeolog Neighboring gene glypican-6 Neighboring gene adaptor related protein complex 4 subunit mu 1 S homeolog Neighboring gene transfer RNA isoleucine (anticodon AAU) Neighboring gene transfer RNA isoleucine (anticodon AAU)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Plx1 is required for chromosomal DNA replication under stressful conditions. Trenz K, et al. EMBO J, 2008 Mar 19. PMID 18309293, Free PMC Article
  2. XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication. Romanowski P, et al. Proc Natl Acad Sci U S A, 1996 Sep 17. PMID 8816774, Free PMC Article
  3. MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. Nishiyama A, et al. Genes Dev, 2011 Jan 15. PMID 21196493, Free PMC Article
  4. Evidence for different MCM subcomplexes with differential binding to chromatin in Xenopus. Coué M, et al. Exp Cell Res, 1998 Dec 15. PMID 9851868
  5. Developmental regulation of MCM replication factors in Xenopus laevis. Sible JC, et al. Curr Biol, 1998 Mar 12. PMID 9512418

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables single-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA strand elongation involved in DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA unwinding involved in DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within DNA unwinding involved in DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair via break-induced replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within premeiotic DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CMG complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MCM complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
  
part_of MCM complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DNA replication licensing factor mcm7-A
Names
CDC47 homolog A
CDC47p
XMCM7
minichromosome maintenance protein 7-A
p90
xMCM7-A
NP_001081466.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087997.1 → NP_001081466.1  DNA replication licensing factor mcm7-A

    See identical proteins and their annotated locations for NP_001081466.1

    Status: PROVISIONAL

    Source sequence(s)
    U51234
    UniProtKB/Swiss-Prot
    O42591, Q6GQ16, Q91876
    Related
    ENSXLAP00005028873.1, ENSXLAT00005029613.1
    Conserved Domains (3) summary
    smart00350
    Location:144 → 640
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:11 → 164
    MCM_N; MCM N-terminal domain
    cl21455
    Location:375 → 514
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    127448772..127473725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91876.2 GenPept UniProtKB/Swiss-Prot:Q91876

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.