porcn.L porcupine O-acyltransferase L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: porcn.L
Official Full Name: porcupine O-acyltransferase L homeolog
Primary source: Xenbase:XB-GENE-921352
Locus tag: XELAEV_18038108mg
See related: EnsemblRapid:ENSXLAG00005018296 AllianceGenome:Xenbase:XB-GENE-921352
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: Xporc; porcn; xporc-d
Summary: Predicted to enable Wnt-protein binding activity and palmitoleoyltransferase activity. Predicted to act upstream of or within several processes, including Wnt protein secretion; Wnt signaling pathway; and protein palmitoylation. Predicted to be located in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human PORCN (porcupine O-acyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 8L

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (667041..673170, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (532677..538806, complement)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

an essential regulatory role of PORCN in shaping Wnt signaling gradients.
Title: Precise regulation of porcupine activity is required for physiological Wnt signaling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables palmitoleoyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt protein secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid modification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein palmitoylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: porcupine O-acyltransferase L homeolog

Names: porcupine homolog L homeolog; porcupine-D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.